Abstract
Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.
| Original language | English |
|---|---|
| Title of host publication | Advances in Applied Microbiology |
| Pages | 237-255 |
| Number of pages | 19 |
| Volume | 91 |
| DOIs | |
| Publication status | Published - 11 Mar 2015 |
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Keywords
- genome, bacterial
- metabolic engineering
- metabolic networks and pathways
- streptomyces
- synthetic biology
Cite this
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Tailoring specialized metabolite production in streptomyces. / Hiltner, Jana K; Hunter, Iain S; Hoskisson, Paul A.
Advances in Applied Microbiology. Vol. 91 2015. p. 237-255.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Tailoring specialized metabolite production in streptomyces
AU - Hiltner, Jana K
AU - Hunter, Iain S
AU - Hoskisson, Paul A
PY - 2015/3/11
Y1 - 2015/3/11
N2 - Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.
AB - Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.
KW - genome, bacterial
KW - metabolic engineering
KW - metabolic networks and pathways
KW - streptomyces
KW - synthetic biology
UR - http://www.sciencedirect.com/science/article/pii/S0065216415000039
U2 - 10.1016/bs.aambs.2015.02.002
DO - 10.1016/bs.aambs.2015.02.002
M3 - Chapter
SN - 978-0-12-802249-8
VL - 91
SP - 237
EP - 255
BT - Advances in Applied Microbiology
ER -