Tailoring specialized metabolite production in streptomyces

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Abstract

Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

Original languageEnglish
Title of host publicationAdvances in Applied Microbiology
Pages237-255
Number of pages19
Volume91
DOIs
Publication statusPublished - 11 Mar 2015

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Keywords

  • genome, bacterial
  • metabolic engineering
  • metabolic networks and pathways
  • streptomyces
  • synthetic biology

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