Tailoring specialized metabolite production in streptomyces

Jana K Hiltner; Iain S Hunter; Paul A Hoskisson

doi:10.1016/bs.aambs.2015.02.002

Tailoring specialized metabolite production in streptomyces

Jana K Hiltner, Iain S Hunter, Paul A Hoskisson

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Citations (Scopus)

Abstract

Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

Original language	English
Title of host publication	Advances in Applied Microbiology
Pages	237-255
Number of pages	19
Volume	91
DOIs	https://doi.org/10.1016/bs.aambs.2015.02.002
Publication status	Published - 11 Mar 2015

Keywords

genome, bacterial
metabolic engineering
metabolic networks and pathways
streptomyces
synthetic biology

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10.1016/bs.aambs.2015.02.002

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abstract = "Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.",

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AB - Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

KW - genome, bacterial

KW - metabolic engineering

KW - metabolic networks and pathways

KW - streptomyces

KW - synthetic biology

UR - http://www.sciencedirect.com/science/article/pii/S0065216415000039

U2 - 10.1016/bs.aambs.2015.02.002

DO - 10.1016/bs.aambs.2015.02.002

M3 - Chapter

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SN - 978-0-12-802249-8

VL - 91

SP - 237

EP - 255

BT - Advances in Applied Microbiology

ER -

Tailoring specialized metabolite production in streptomyces

Abstract

Keywords

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