Tailoring specialized metabolite production in streptomyces

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

LanguageEnglish
Title of host publicationAdvances in Applied Microbiology
Pages237-255
Number of pages19
Volume91
DOIs
Publication statusPublished - 11 Mar 2015

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Streptomyces
Metabolic Networks and Pathways
Synthetic Biology
Genes

Keywords

  • genome, bacterial
  • metabolic engineering
  • metabolic networks and pathways
  • streptomyces
  • synthetic biology

Cite this

Hiltner, Jana K ; Hunter, Iain S ; Hoskisson, Paul A. / Tailoring specialized metabolite production in streptomyces. Advances in Applied Microbiology. Vol. 91 2015. pp. 237-255
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Tailoring specialized metabolite production in streptomyces. / Hiltner, Jana K; Hunter, Iain S; Hoskisson, Paul A.

Advances in Applied Microbiology. Vol. 91 2015. p. 237-255.

Research output: Chapter in Book/Report/Conference proceedingChapter

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