T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection: is this paradigm still relevant?

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4mice in the 1990s questioned the paramount role of thisTh2 archetypal cytokine in the non-healing response to Leishmania infection. The more recent characterization of CD4 T cell regulatory populations and further effector CD4 T helper populations, Th17, Th9, and T follicular (f)h cells as well as the acknowledged plasticity in T helper cell function has further added to the complexity of host pathogen interactions.These interactions are complicated by the multiplicity of cells that respond to CD4 T cell subset signatory cytokines, as well as the diversity of Leishmania species that are often subject to significantly different immuneregulatory controls. In this article we review current knowledge with regard to the role of CD4 T cells and their products during Leishmania infection. In particular we update on our studies using conditional IL-4Rα gene-deficient mice that have allowed dissection of the cell interplay dictating the disease outcomes of the major Leishmania species infecting humans.
LanguageEnglish
Article number80
Number of pages13
JournalFrontiers in Immunology
Volume3
Issue numberAPR
DOIs
Publication statusPublished - 17 Apr 2012

Fingerprint

Leishmania
Leishmania major
Regulatory T-Lymphocytes
Infection
Cytokines
Population
Host-Pathogen Interactions
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Dissection
T-Lymphocytes
Genes

Keywords

  • Leishmania
  • T helper 1
  • T helper 2
  • T regulatory cells
  • T helper 17
  • T follicular helper cells
  • interleukin-4
  • interferon-gamma

Cite this

@article{52e39fe6efcd4ed98d05c905dbec95b7,
title = "T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection: is this paradigm still relevant?",
abstract = "Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4mice in the 1990s questioned the paramount role of thisTh2 archetypal cytokine in the non-healing response to Leishmania infection. The more recent characterization of CD4 T cell regulatory populations and further effector CD4 T helper populations, Th17, Th9, and T follicular (f)h cells as well as the acknowledged plasticity in T helper cell function has further added to the complexity of host pathogen interactions.These interactions are complicated by the multiplicity of cells that respond to CD4 T cell subset signatory cytokines, as well as the diversity of Leishmania species that are often subject to significantly different immuneregulatory controls. In this article we review current knowledge with regard to the role of CD4 T cells and their products during Leishmania infection. In particular we update on our studies using conditional IL-4Rα gene-deficient mice that have allowed dissection of the cell interplay dictating the disease outcomes of the major Leishmania species infecting humans.",
keywords = "Leishmania, T helper 1, T helper 2, T regulatory cells, T helper 17, T follicular helper cells, interleukin-4, interferon-gamma",
author = "J. Alexander and F. Brombacher",
year = "2012",
month = "4",
day = "17",
doi = "10.3389/fimmu.2012.00080",
language = "English",
volume = "3",
journal = "Frontiers in Immunology",
issn = "1664-3224",
number = "APR",

}

TY - JOUR

T1 - T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection

T2 - Frontiers in Immunology

AU - Alexander, J.

AU - Brombacher, F.

PY - 2012/4/17

Y1 - 2012/4/17

N2 - Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4mice in the 1990s questioned the paramount role of thisTh2 archetypal cytokine in the non-healing response to Leishmania infection. The more recent characterization of CD4 T cell regulatory populations and further effector CD4 T helper populations, Th17, Th9, and T follicular (f)h cells as well as the acknowledged plasticity in T helper cell function has further added to the complexity of host pathogen interactions.These interactions are complicated by the multiplicity of cells that respond to CD4 T cell subset signatory cytokines, as well as the diversity of Leishmania species that are often subject to significantly different immuneregulatory controls. In this article we review current knowledge with regard to the role of CD4 T cells and their products during Leishmania infection. In particular we update on our studies using conditional IL-4Rα gene-deficient mice that have allowed dissection of the cell interplay dictating the disease outcomes of the major Leishmania species infecting humans.

AB - Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4mice in the 1990s questioned the paramount role of thisTh2 archetypal cytokine in the non-healing response to Leishmania infection. The more recent characterization of CD4 T cell regulatory populations and further effector CD4 T helper populations, Th17, Th9, and T follicular (f)h cells as well as the acknowledged plasticity in T helper cell function has further added to the complexity of host pathogen interactions.These interactions are complicated by the multiplicity of cells that respond to CD4 T cell subset signatory cytokines, as well as the diversity of Leishmania species that are often subject to significantly different immuneregulatory controls. In this article we review current knowledge with regard to the role of CD4 T cells and their products during Leishmania infection. In particular we update on our studies using conditional IL-4Rα gene-deficient mice that have allowed dissection of the cell interplay dictating the disease outcomes of the major Leishmania species infecting humans.

KW - Leishmania

KW - T helper 1

KW - T helper 2

KW - T regulatory cells

KW - T helper 17

KW - T follicular helper cells

KW - interleukin-4

KW - interferon-gamma

UR - http://www.scopus.com/inward/record.url?scp=84873495696&partnerID=8YFLogxK

UR - http://www.frontiersin.org/Microbial_Immunology

U2 - 10.3389/fimmu.2012.00080

DO - 10.3389/fimmu.2012.00080

M3 - Article

VL - 3

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - APR

M1 - 80

ER -