Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae)

Enitome Bafor, C. V. Lim, Edward Rowan, Ruangelie Edrada-Ebel

Research output: Contribution to conferencePoster

Abstract

New potential lead uterine active agents for the safe and effective management and/or therapy of dysfunctional uterine activities were isolated from the leaves of the tropical plant F. exasperata via in vitro bioassay-guided functional uterine assays as well as several spectroscopic procedures which included 1D, 2D NMR and LC-HRMS. A total of 17 active compounds comprising four fatty acids, one triglyceride, six pheophorbide related compounds, four flavonoids, one pyrimidine, and an inorganic salt were identified from the ethylacetate and methanol extracts. Metabolomic tools were used to further investigate pathways that were down and/or up regulated during uterine activities.
Original languageEnglish
PagesPG10
Number of pages1
DOIs
Publication statusPublished - Jul 2012
EventAmerican Society of Pharmacognosy Meeting : 2012 Annual Meeting - New York, United States
Duration: 28 Jul 201231 Jul 2012

Conference

ConferenceAmerican Society of Pharmacognosy Meeting : 2012 Annual Meeting
CountryUnited States
CityNew York
Period28/07/1231/07/12

Keywords

  • dysfunctional uterine activities
  • F. exasperata
  • ethylacetate extracts
  • methanol extracts
  • pharmacology, toxicology and pharmaceutics
  • applied microbiology and biotechnology

Cite this

Bafor, E., Lim, C. V., Rowan, E., & Edrada-Ebel, R. (2012). Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae). PG10. Poster session presented at American Society of Pharmacognosy Meeting : 2012 Annual Meeting, New York, United States. https://doi.org/10.1055/s-0032-1320653