Abstract
New potential lead uterine active agents for the safe and effective management and/or therapy of dysfunctional uterine activities were isolated from the leaves of the tropical plant F. exasperata via in vitro bioassay-guided functional uterine assays as well as several spectroscopic procedures which included 1D, 2D NMR and LC-HRMS. A total of 17 active compounds comprising four fatty acids, one triglyceride, six pheophorbide related compounds, four flavonoids, one pyrimidine, and an inorganic salt were identified from the ethylacetate and methanol extracts. Metabolomic tools were used to further investigate pathways that were down and/or up regulated during uterine activities.
Original language | English |
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Pages | PG10 |
Number of pages | 1 |
DOIs | |
Publication status | Published - Jul 2012 |
Event | American Society of Pharmacognosy Meeting : 2012 Annual Meeting - New York, United States Duration: 28 Jul 2012 → 31 Jul 2012 |
Conference
Conference | American Society of Pharmacognosy Meeting : 2012 Annual Meeting |
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Country/Territory | United States |
City | New York |
Period | 28/07/12 → 31/07/12 |
Keywords
- dysfunctional uterine activities
- F. exasperata
- ethylacetate extracts
- methanol extracts
- pharmacology, toxicology and pharmaceutics
- applied microbiology and biotechnology