System analysis of a programmed cell death model

Eric Bullinger

Research output: Contribution to conferencePaper

9 Citations (Scopus)

Abstract

Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.

Conference

Conference44th IEEE Conference on Decision and Control and European Control Conference
Abbreviated titleCDC-ECC
CountrySpain
CitySeville
Period12/12/0515/12/05

Fingerprint

systems analysis
apoptosis
time lag
organisms
differential equations
switches
trajectories
cells

Keywords

  • cell death model
  • apoptosis
  • apoptosis models

Cite this

Bullinger, E. (2006). System analysis of a programmed cell death model. 7994-7999. Paper presented at 44th IEEE Conference on Decision and Control and European Control Conference , Seville, Spain. https://doi.org/10.1109/CDC.2005.1583455
Bullinger, Eric. / System analysis of a programmed cell death model. Paper presented at 44th IEEE Conference on Decision and Control and European Control Conference , Seville, Spain.6 p.
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abstract = "Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.",
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year = "2006",
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Bullinger, E 2006, 'System analysis of a programmed cell death model' Paper presented at 44th IEEE Conference on Decision and Control and European Control Conference , Seville, Spain, 12/12/05 - 15/12/05, pp. 7994-7999. https://doi.org/10.1109/CDC.2005.1583455

System analysis of a programmed cell death model. / Bullinger, Eric.

2006. 7994-7999 Paper presented at 44th IEEE Conference on Decision and Control and European Control Conference , Seville, Spain.

Research output: Contribution to conferencePaper

TY - CONF

T1 - System analysis of a programmed cell death model

AU - Bullinger, Eric

PY - 2006

Y1 - 2006

N2 - Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.

AB - Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.

KW - cell death model

KW - apoptosis

KW - apoptosis models

U2 - 10.1109/CDC.2005.1583455

DO - 10.1109/CDC.2005.1583455

M3 - Paper

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Bullinger E. System analysis of a programmed cell death model. 2006. Paper presented at 44th IEEE Conference on Decision and Control and European Control Conference , Seville, Spain. https://doi.org/10.1109/CDC.2005.1583455