System analysis of a programmed cell death model

Eric Bullinger

doi:10.1109/CDC.2005.1583455

System analysis of a programmed cell death model

Eric Bullinger

Electronic And Electrical Engineering

Research output: Contribution to conference › Paper

9 Citations (Scopus)

Abstract

Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.

Original language	English
Pages	7994-7999
Number of pages	6
DOIs	https://doi.org/10.1109/CDC.2005.1583455
Publication status	Published - 2006
Event	44th IEEE Conference on Decision and Control and European Control Conference - Seville, Spain Duration: 12 Dec 2005 → 15 Dec 2005

Conference

Conference	44th IEEE Conference on Decision and Control and European Control Conference
Abbreviated title	CDC-ECC
Country/Territory	Spain
City	Seville
Period	12/12/05 → 15/12/05

Keywords

cell death model
apoptosis
apoptosis models

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10.1109/CDC.2005.1583455

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title = "System analysis of a programmed cell death model",

abstract = "Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.",

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AB - Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.

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KW - apoptosis

KW - apoptosis models

U2 - 10.1109/CDC.2005.1583455

DO - 10.1109/CDC.2005.1583455

M3 - Paper

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T2 - 44th IEEE Conference on Decision and Control and European Control Conference

Y2 - 12 December 2005 through 15 December 2005

ER -

System analysis of a programmed cell death model

Abstract

Conference

Keywords

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Cite this