System analysis of a programmed cell death model

Eric Bullinger

Research output: Contribution to conferencePaper

9 Citations (Scopus)

Abstract

Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.
Original languageEnglish
Pages7994-7999
Number of pages6
DOIs
Publication statusPublished - 2006
Event44th IEEE Conference on Decision and Control and European Control Conference - Seville, Spain
Duration: 12 Dec 200515 Dec 2005

Conference

Conference44th IEEE Conference on Decision and Control and European Control Conference
Abbreviated titleCDC-ECC
CountrySpain
CitySeville
Period12/12/0515/12/05

Keywords

  • cell death model
  • apoptosis
  • apoptosis models

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