Synthetic Porphyrins/Metalloporphyrins Which Mimic States in Catalytic Cycle of Cytochrome P-450 and Peroxidases

N N DAEID, S T ATKINSON, K B NOLAN

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The reaction of thiolates, RS-, having electron withdrawing groups with iron(III) tetra-arylporphyrins in DMSO,in air gives low-spin Fe(III)-P(-SR)2, having hyperporphyrin spectra similar to thiolate derivatives of cytochrome P-450. Removal of air gives high spin Fe(II)-P(-SR) which on addition of CO results in H+ uptake and formation of Fe(II)-P(SHR)CO. Addition of thiols and base to the iron(III) porphyrins in toluene in the absence of air gives 4-coordinate Fe(II)-P which in the presence of CO gives Fe(II)-P(SHR)CO. Metal complexes of one of the porphyrins studied i.e. a tetraphenolic porphyrin undergo 2e- oxidation in air to give quinonoid species which oxidise peroxidase substrates. Rate constants for some of these reactions are reported.

Original languageEnglish
Pages (from-to)1541-1548
Number of pages8
JournalPure and Applied Chemistry
Volume65
Issue number7
DOIs
Publication statusPublished - Jul 1993

Keywords

  • facile area oxidation
  • polyvalent porphyrins
  • complexes

Fingerprint Dive into the research topics of 'Synthetic Porphyrins/Metalloporphyrins Which Mimic States in Catalytic Cycle of Cytochrome P-450 and Peroxidases'. Together they form a unique fingerprint.

Cite this