Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(ii) complex that can be photolyzed by visible light

Jesús Mosquera, Mateo I. Sánchez, José L. Mascareñas, M. Eugenio Vázquez

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis of caged-histidine peptides that can be readily deprotected by irradiation with visible light, and demonstrated the application of this approach for the photocontrol of the activity of Ni(ii)-dependent peptide nucleases. 

Original languageEnglish
Pages (from-to)5501-5504
Number of pages4
JournalChemical Communications
Volume51
Issue number25
DOIs
Publication statusPublished - 28 Mar 2015

Keywords

  • synthetic peptides
  • light-sensitive histidine

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