Synthesis, structural authentication, and structurally defined metalation reactions of lithium and sodium da-zincate bases (da = diisopropylamide) with phenylacetylene

W. Clegg, J. Garcia-Alvarez, P. Garcia-Alvarez, D.V. Graham, R.W. Harrington, E. Hevia, A.R. Kennedy, R.E. Mulvey

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In a study aimed at developing the diisopropylamido (DA) chemistry of zincates, the new lithium DA-zincate [(TMEDA)·Li(tBu)(DA)Zn(tBu)] (4) has been synthesized by an interlocking cocomplexation approach comprising mixing of its three component chemicals, LDA, tBu2Zn, and TMEDA, in a 1:1:1 ratio in hexane solution. Previously made by transamination from the corresponding TMP-zincate, the known sodium congener [(TMEDA)·Na(tBu)(DA)Zn(tBu)] (2) was also synthesized by this approach, substituting NaDA for LDA. Closely resembling each other, their molecular structures determined by X-ray crystallography can be categorized as contact ion-pair ates of TMEDA-chelated alkali metal cations linked to trigonal-planar dialkyl-Zn anions via bridging DA ligands. Reaction of 4 and 2 with phenylacetylene affords the bimetallic acetylides [{(TMEDA)·Li(CCPh)2Zn(tBu)}2·(TMEDA)] (5) and [{(TMEDA)·Na(CCPh)2Zn(tBu)}2 ] (6), respectively. X-ray crystallographic studies reveal 5 is a pseudodimer (tetranuclear) with two (LiCZnC) rings linked at the Zn atoms by a bridging, nonchelating TMEDA ligand; in contrast 6 adopts a distorted cubane of alternating PhCC and metal (2 Na, 2 Zn) corners. For comparison, the synthesis and crystal structures of the neutral zinc complexes [(TMEDA)·Zn(CCPh)2] (7) and [(TMEDA)·Zn(tBu)(CCPh)] (8), formally components of the ate complexes 5 and 6, are also reported. In addition, the 1H and 13C NMR spectra of 2, 4, 5, 6, 7, and 8 recorded from solutions in C6D6 are disclosed. (Abstract from: http://pubs.acs.org/doi/abs/10.1021/om8001813)
LanguageEnglish
Pages2654-2663
Number of pages9
JournalOrganometallics
Volume27
Issue number11
DOIs
Publication statusPublished - 9 Jun 2008

Fingerprint

Lithium
Authentication
lithium
Sodium
sodium
congeners
cubane
ligands
synthesis
alkali metals
locking
crystallography
x rays
molecular structure
zinc
chemistry
anions
cations
nuclear magnetic resonance
crystal structure

Keywords

  • synthesis
  • structural authentication
  • structurally defined
  • metalation
  • reactions
  • lithium
  • sodium da-zincate bases (da = diisopropylamide)
  • phenylacetylene

Cite this

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abstract = "In a study aimed at developing the diisopropylamido (DA) chemistry of zincates, the new lithium DA-zincate [(TMEDA)·Li(tBu)(DA)Zn(tBu)] (4) has been synthesized by an interlocking cocomplexation approach comprising mixing of its three component chemicals, LDA, tBu2Zn, and TMEDA, in a 1:1:1 ratio in hexane solution. Previously made by transamination from the corresponding TMP-zincate, the known sodium congener [(TMEDA)·Na(tBu)(DA)Zn(tBu)] (2) was also synthesized by this approach, substituting NaDA for LDA. Closely resembling each other, their molecular structures determined by X-ray crystallography can be categorized as contact ion-pair ates of TMEDA-chelated alkali metal cations linked to trigonal-planar dialkyl-Zn anions via bridging DA ligands. Reaction of 4 and 2 with phenylacetylene affords the bimetallic acetylides [{(TMEDA)·Li(CCPh)2Zn(tBu)}2·(TMEDA)] (5) and [{(TMEDA)·Na(CCPh)2Zn(tBu)}2 ] (6), respectively. X-ray crystallographic studies reveal 5 is a pseudodimer (tetranuclear) with two (LiCZnC) rings linked at the Zn atoms by a bridging, nonchelating TMEDA ligand; in contrast 6 adopts a distorted cubane of alternating PhCC and metal (2 Na, 2 Zn) corners. For comparison, the synthesis and crystal structures of the neutral zinc complexes [(TMEDA)·Zn(CCPh)2] (7) and [(TMEDA)·Zn(tBu)(CCPh)] (8), formally components of the ate complexes 5 and 6, are also reported. In addition, the 1H and 13C NMR spectra of 2, 4, 5, 6, 7, and 8 recorded from solutions in C6D6 are disclosed. (Abstract from: http://pubs.acs.org/doi/abs/10.1021/om8001813)",
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Synthesis, structural authentication, and structurally defined metalation reactions of lithium and sodium da-zincate bases (da = diisopropylamide) with phenylacetylene. / Clegg, W.; Garcia-Alvarez, J.; Garcia-Alvarez, P.; Graham, D.V.; Harrington, R.W.; Hevia, E.; Kennedy, A.R.; Mulvey, R.E.

In: Organometallics, Vol. 27, No. 11, 09.06.2008, p. 2654-2663.

Research output: Contribution to journalArticle

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AU - Clegg, W.

AU - Garcia-Alvarez, J.

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AU - Graham, D.V.

AU - Harrington, R.W.

AU - Hevia, E.

AU - Kennedy, A.R.

AU - Mulvey, R.E.

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N2 - In a study aimed at developing the diisopropylamido (DA) chemistry of zincates, the new lithium DA-zincate [(TMEDA)·Li(tBu)(DA)Zn(tBu)] (4) has been synthesized by an interlocking cocomplexation approach comprising mixing of its three component chemicals, LDA, tBu2Zn, and TMEDA, in a 1:1:1 ratio in hexane solution. Previously made by transamination from the corresponding TMP-zincate, the known sodium congener [(TMEDA)·Na(tBu)(DA)Zn(tBu)] (2) was also synthesized by this approach, substituting NaDA for LDA. Closely resembling each other, their molecular structures determined by X-ray crystallography can be categorized as contact ion-pair ates of TMEDA-chelated alkali metal cations linked to trigonal-planar dialkyl-Zn anions via bridging DA ligands. Reaction of 4 and 2 with phenylacetylene affords the bimetallic acetylides [{(TMEDA)·Li(CCPh)2Zn(tBu)}2·(TMEDA)] (5) and [{(TMEDA)·Na(CCPh)2Zn(tBu)}2 ] (6), respectively. X-ray crystallographic studies reveal 5 is a pseudodimer (tetranuclear) with two (LiCZnC) rings linked at the Zn atoms by a bridging, nonchelating TMEDA ligand; in contrast 6 adopts a distorted cubane of alternating PhCC and metal (2 Na, 2 Zn) corners. For comparison, the synthesis and crystal structures of the neutral zinc complexes [(TMEDA)·Zn(CCPh)2] (7) and [(TMEDA)·Zn(tBu)(CCPh)] (8), formally components of the ate complexes 5 and 6, are also reported. In addition, the 1H and 13C NMR spectra of 2, 4, 5, 6, 7, and 8 recorded from solutions in C6D6 are disclosed. (Abstract from: http://pubs.acs.org/doi/abs/10.1021/om8001813)

AB - In a study aimed at developing the diisopropylamido (DA) chemistry of zincates, the new lithium DA-zincate [(TMEDA)·Li(tBu)(DA)Zn(tBu)] (4) has been synthesized by an interlocking cocomplexation approach comprising mixing of its three component chemicals, LDA, tBu2Zn, and TMEDA, in a 1:1:1 ratio in hexane solution. Previously made by transamination from the corresponding TMP-zincate, the known sodium congener [(TMEDA)·Na(tBu)(DA)Zn(tBu)] (2) was also synthesized by this approach, substituting NaDA for LDA. Closely resembling each other, their molecular structures determined by X-ray crystallography can be categorized as contact ion-pair ates of TMEDA-chelated alkali metal cations linked to trigonal-planar dialkyl-Zn anions via bridging DA ligands. Reaction of 4 and 2 with phenylacetylene affords the bimetallic acetylides [{(TMEDA)·Li(CCPh)2Zn(tBu)}2·(TMEDA)] (5) and [{(TMEDA)·Na(CCPh)2Zn(tBu)}2 ] (6), respectively. X-ray crystallographic studies reveal 5 is a pseudodimer (tetranuclear) with two (LiCZnC) rings linked at the Zn atoms by a bridging, nonchelating TMEDA ligand; in contrast 6 adopts a distorted cubane of alternating PhCC and metal (2 Na, 2 Zn) corners. For comparison, the synthesis and crystal structures of the neutral zinc complexes [(TMEDA)·Zn(CCPh)2] (7) and [(TMEDA)·Zn(tBu)(CCPh)] (8), formally components of the ate complexes 5 and 6, are also reported. In addition, the 1H and 13C NMR spectra of 2, 4, 5, 6, 7, and 8 recorded from solutions in C6D6 are disclosed. (Abstract from: http://pubs.acs.org/doi/abs/10.1021/om8001813)

KW - synthesis

KW - structural authentication

KW - structurally defined

KW - metalation

KW - reactions

KW - lithium

KW - sodium da-zincate bases (da = diisopropylamide)

KW - phenylacetylene

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DO - 10.1021/om8001813

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VL - 27

SP - 2654

EP - 2663

JO - Organometallics

T2 - Organometallics

JF - Organometallics

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