Synthesis, processing and solid state excipient interactions of cucurbit[6]uril and its formulation into tablets for oral drug delivery

Shonagh Walker, Rajdip Kaur, Fiona J McInnes, Nial J Wheate

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The synthesis, processing, and solid state excipient interactions of cucurbit[6]uril (CB[6]) and its formulation into oral tablets has been examined using a range of physical chemistry techniques. Rapid precipitation from HCl by the addition of water yields microcrystalline CB[6] with smaller and more consistent particle size (30-165 μm) compared with the sieved CB[6] (50-540 μm) produced from large crystals grown by slow evaporation from HCl. The microcrystalline particles also contain fewer water molecules in the crystal compared with the sieved particles: 10 and 16% respectively. Microcrystalline CB[6] can be formulated into tablets suitable for oral delivery with a CB[6] content of 1-50% w/w, with the other excipients including lactose, talc, Avicel, magnesium stearate and Ac-Di-Sol. In the solid state microcrystalline CB[6] does not interact significantly with the talc, Ac-Di-Sol or Avicel, but significant interactions are observed when mixed or ground with either magnesium stearate or lactose, resulting in the lowering of the melting points of both excipients. This work represents the first study of the physical processing and solid state chemistry of CB[n]s for pharmaceutical formulation and represents an important development step in the use of CB[n]s as drug delivery vehicles.
Original languageEnglish
Pages (from-to)2166-2172
Number of pages7
JournalMolecular Pharmaceutics
Volume7
Issue number6
DOIs
Publication statusPublished - 16 Jul 2010

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Excipients
Tablets
Pharmaceutical Preparations
Talc
Polymethyl Methacrylate
Lactose
Cellulose
Physical Chemistry
Drug Compounding
Water
Particle Size
Freezing
cucurbit(6)uril

Keywords

  • bridged compounds
  • physical chemistry
  • crystallography
  • drug delivery systems
  • imidazoles
  • molecular models
  • molecular structure
  • particle size
  • tablets
  • X-ray

Cite this

Walker, Shonagh ; Kaur, Rajdip ; McInnes, Fiona J ; Wheate, Nial J. / Synthesis, processing and solid state excipient interactions of cucurbit[6]uril and its formulation into tablets for oral drug delivery. In: Molecular Pharmaceutics. 2010 ; Vol. 7, No. 6. pp. 2166-2172.
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Synthesis, processing and solid state excipient interactions of cucurbit[6]uril and its formulation into tablets for oral drug delivery. / Walker, Shonagh; Kaur, Rajdip; McInnes, Fiona J; Wheate, Nial J.

In: Molecular Pharmaceutics, Vol. 7, No. 6, 16.07.2010, p. 2166-2172.

Research output: Contribution to journalArticle

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