One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5– exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (ΔJ = 1) for [TbL3]– and 0.241 (ΔJ = 1) for [TbL4]5– in buffer solutions were recorded.
- imaging agents
- magnetic resonance imaging
- molecular structure
- twisted square antiprism isomers
- circularly polarized luminescence (CPL)
- water-soluble chiral DOTA lanthanide complexes