Synthesis of water-soluble chiral DOTA lanthanide complexes with predominantly twisted square antiprism isomers and circularly polarized luminescence

Lixiong Dai, Junhui Zhang, Yuqing Chen, Lewis E. MacKenzie, Robert Pal, Ga-Lai Law

Research output: Contribution to journalArticlepeer-review

Abstract

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5– exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (ΔJ = 1) for [TbL3]– and 0.241 (ΔJ = 1) for [TbL4]5– in buffer solutions were recorded.
Original languageEnglish
Pages (from-to)12506–12510
Number of pages5
JournalInorganic Chemistry
Volume58
DOIs
Publication statusPublished - 6 Sep 2019

Keywords

  • imaging agents
  • luminescence
  • magnetic resonance imaging
  • molecular structure
  • solubility
  • twisted square antiprism isomers
  • circularly polarized luminescence (CPL)
  • water-soluble chiral DOTA lanthanide complexes

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