Synthesis of selective inhibitors of sphingosine kinase 1

Dong Jae Baek, Neil MacRitchie, Nigel Pyne, Susan Pyne, Robert Bittman

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC50 = 3.6 lM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.
LanguageEnglish
Number of pages4
JournalChemical Communications (London)
Early online date28 Jan 2013
DOIs
Publication statusPublished - 2013

Fingerprint

Protein Isoforms
Sphingosine
Muscle
Cells
Degradation
sphingosine kinase
1-(4-octylphenethyl)piperidin-4-ol

Keywords

  • synthesis
  • selective inhibitors
  • sphingosine kinase 1

Cite this

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Synthesis of selective inhibitors of sphingosine kinase 1. / Baek, Dong Jae; MacRitchie, Neil; Pyne, Nigel; Pyne, Susan; Bittman, Robert.

In: Chemical Communications (London), 2013.

Research output: Contribution to journalArticle

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