Synthesis of selective inhibitors of sphingosine kinase 1

Dong Jae Baek, Neil MacRitchie, Nigel Pyne, Susan Pyne, Robert Bittman

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC50 = 3.6 lM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.
Original languageEnglish
Number of pages4
JournalChemical Communications (London)
Early online date28 Jan 2013
DOIs
Publication statusPublished - 2013

Keywords

  • synthesis
  • selective inhibitors
  • sphingosine kinase 1

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