Synthesis of potential inhibitors of GTP-cyclohydrolase I: an efficient synthesis of 8-substituted 7-deazaguanines

Colin L. Gibson; Klaus Paulini; Colin J. Suckling

doi:10.1039/a608297a

Synthesis of potential inhibitors of GTP-cyclohydrolase I: an efficient synthesis of 8-substituted 7-deazaguanines

Colin L. Gibson, Klaus Paulini, Colin J. Suckling^*

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A novel two step synthesis of 8-substituted 7-deazaguanines is developed and involves the regioselective alkylation of pyrimidinones 1a and 1b with nitrosoalkenes derived from α-halo oximes followed by transoximation to give the 7-deazaguanines 6a-d in 41-65% overall yield.

Original language	English
Pages (from-to)	371-372
Number of pages	2
Journal	Chemical Communications
Issue number	4
DOIs	https://doi.org/10.1039/a608297a
Publication status	Published - 1997

Keywords

synthesis of 8-substituted 7-deazaguanines

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10.1039/a608297a

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title = "Synthesis of potential inhibitors of GTP-cyclohydrolase I: an efficient synthesis of 8-substituted 7-deazaguanines",

abstract = "A novel two step synthesis of 8-substituted 7-deazaguanines is developed and involves the regioselective alkylation of pyrimidinones 1a and 1b with nitrosoalkenes derived from α-halo oximes followed by transoximation to give the 7-deazaguanines 6a-d in 41-65\% overall yield.",

keywords = "synthesis of 8-substituted 7-deazaguanines",

author = "Gibson, \{Colin L.\} and Klaus Paulini and Suckling, \{Colin J.\}",

year = "1997",

doi = "10.1039/a608297a",

language = "English",

pages = "371--372",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "4",

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T1 - Synthesis of potential inhibitors of GTP-cyclohydrolase I

T2 - an efficient synthesis of 8-substituted 7-deazaguanines

AU - Gibson, Colin L.

AU - Paulini, Klaus

AU - Suckling, Colin J.

PY - 1997

Y1 - 1997

N2 - A novel two step synthesis of 8-substituted 7-deazaguanines is developed and involves the regioselective alkylation of pyrimidinones 1a and 1b with nitrosoalkenes derived from α-halo oximes followed by transoximation to give the 7-deazaguanines 6a-d in 41-65% overall yield.

AB - A novel two step synthesis of 8-substituted 7-deazaguanines is developed and involves the regioselective alkylation of pyrimidinones 1a and 1b with nitrosoalkenes derived from α-halo oximes followed by transoximation to give the 7-deazaguanines 6a-d in 41-65% overall yield.

KW - synthesis of 8-substituted 7-deazaguanines

UR - https://www.scopus.com/pages/publications/0013550032

U2 - 10.1039/a608297a

DO - 10.1039/a608297a

M3 - Article

AN - SCOPUS:0013550032

SN - 1359-7345

SP - 371

EP - 372

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Synthesis of potential inhibitors of GTP-cyclohydrolase I: an efficient synthesis of 8-substituted 7-deazaguanines

Abstract

Keywords

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