Abstract
| Language | Undefined/Unknown |
|---|---|
| Pages | 264-265 |
| Number of pages | 2 |
| Journal | International Journal of Chemical Research |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 |
Keywords
- dna binding agents
- bis-netropsin
- binding agents
Cite this
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Synthesis of novel DNA binding agents: indole-containing analogs of bis-netropsin. / Khalaf, Abedawn I.; Pitt, Andrew R.; Scobie, Martin; Suckling, Colin J.; Urwin, John; Waigh, Roger D.; Fishleigh, Robert V.; Young, Stephen C.
In: International Journal of Chemical Research, No. 6, 2000, p. 264-265.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis of novel DNA binding agents: indole-containing analogs of bis-netropsin
AU - Khalaf, Abedawn I.
AU - Pitt, Andrew R.
AU - Scobie, Martin
AU - Suckling, Colin J.
AU - Urwin, John
AU - Waigh, Roger D.
AU - Fishleigh, Robert V.
AU - Young, Stephen C.
PY - 2000
Y1 - 2000
N2 - Mol. modeling studies showed that indole dicarboxylic acids are potential linkers for the synthesis of bisnetropsin analogs with a good fit to the minor groove of DNA. To test this hypothesis, 2-carboxyindole-6-acetic acid, indole-2,6-dicarboxylic acid, 6-(2-carboxyethyl)indole-2-carboxylic acid, and 6-(2-carboxy-1-ethenyl)indole-2-carboxylic acid were prepd. and coupled to 3-[1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido]dimethylaminopropane. Similarly, indole-2,5-dicarboxylic acid was prepd. and coupled to 3-[1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido]propionamidine hydrochloride. Some derivs. showed esp. strong binding at AT rich regions as shown by footprinting studies.
AB - Mol. modeling studies showed that indole dicarboxylic acids are potential linkers for the synthesis of bisnetropsin analogs with a good fit to the minor groove of DNA. To test this hypothesis, 2-carboxyindole-6-acetic acid, indole-2,6-dicarboxylic acid, 6-(2-carboxyethyl)indole-2-carboxylic acid, and 6-(2-carboxy-1-ethenyl)indole-2-carboxylic acid were prepd. and coupled to 3-[1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido]dimethylaminopropane. Similarly, indole-2,5-dicarboxylic acid was prepd. and coupled to 3-[1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido]propionamidine hydrochloride. Some derivs. showed esp. strong binding at AT rich regions as shown by footprinting studies.
KW - dna binding agents
KW - bis-netropsin
KW - binding agents
U2 - 10.3184/030823400103167444
DO - 10.3184/030823400103167444
M3 - Article
SP - 264
EP - 265
JO - International Journal of Chemical Research
T2 - International Journal of Chemical Research
JF - International Journal of Chemical Research
SN - 0975-3699
IS - 6
ER -