Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

Calum William Muir, Alan Kennedy, Joanna Redmond, Allan Watson

Research output: Contribution to journalArticle

27 Citations (Scopus)
165 Downloads (Pure)

Abstract

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups
Original languageEnglish
Pages (from-to)3337-3340
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number20
Early online date26 Mar 2013
DOIs
Publication statusPublished - 28 May 2013

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Cyclization
Functional groups
emerging
synthesis

Keywords

  • synthesis
  • functionalised 4H-quinolizin-4-ones
  • tandem
  • horner-wadsworth-emmons
  • olefination/cyclisation
  • facile access
  • key pharmacophores

Cite this

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Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation. / Muir, Calum William; Kennedy, Alan; Redmond, Joanna; Watson, Allan.

In: Organic and Biomolecular Chemistry, Vol. 11, No. 20, 28.05.2013, p. 3337-3340 .

Research output: Contribution to journalArticle

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