Abstract
4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups
Original language | English |
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Pages (from-to) | 3337-3340 |
Number of pages | 4 |
Journal | Organic and Biomolecular Chemistry |
Volume | 11 |
Issue number | 20 |
Early online date | 26 Mar 2013 |
DOIs | |
Publication status | Published - 28 May 2013 |
Keywords
- synthesis
- functionalised 4H-quinolizin-4-ones
- tandem
- horner-wadsworth-emmons
- olefination/cyclisation
- facile access
- key pharmacophores