Synthesis of core-shell molecularly imprinted polymer microspheres by precipitation polymerization for the inline molecularly imprinted solid-phase extraction of thiabendazole from citrus fruits and orange juice samples

Francisco Barahona, Esther Turiel, Peter A. G. Cormack, Antonio. Martin-Esteban

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

In this work, the synthesis of molecularly imprinted polymer microspheres with narrow particle size distributions and core-shell morphol. by a two-step pptn. polymn. procedure is described. Polydivinylbenzene (poly DVB-80) core particles were used as seed particles in the prodn. of molecularly imprinted polymer shells by copolymn. of divinylbenzene-80 with methacrylic acid in the presence of thiabendazole (TBZ) and an appropriate porogen. Thereafter, polymer particles were packed into refillable stainless steel HPLC columns used in the development of an inline molecularly imprinted SPE method for the detn. of TBZ in citrus fruits and orange juice samples. Under optimized chromatog. conditions, recoveries of TBZ within the range 81.1-106.4%, depending upon the sample, were obtained, with RSDs lower than 10%. This novel method permits the unequivocal detn. of TBZ in the samples under study, according to the max. residue levels allowed within Europe, in less than 20 min and without any need for a clean-up step in the anal. protocol.
LanguageUndefined/Unknown
Pages217-224
Number of pages8
JournalJournal of Separation Science
Volume34
Issue number2
DOIs
Publication statusPublished - 2011

Keywords

  • polymer microspheres
  • polymerization
  • thiabendazole

Cite this

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title = "Synthesis of core-shell molecularly imprinted polymer microspheres by precipitation polymerization for the inline molecularly imprinted solid-phase extraction of thiabendazole from citrus fruits and orange juice samples",
abstract = "In this work, the synthesis of molecularly imprinted polymer microspheres with narrow particle size distributions and core-shell morphol. by a two-step pptn. polymn. procedure is described. Polydivinylbenzene (poly DVB-80) core particles were used as seed particles in the prodn. of molecularly imprinted polymer shells by copolymn. of divinylbenzene-80 with methacrylic acid in the presence of thiabendazole (TBZ) and an appropriate porogen. Thereafter, polymer particles were packed into refillable stainless steel HPLC columns used in the development of an inline molecularly imprinted SPE method for the detn. of TBZ in citrus fruits and orange juice samples. Under optimized chromatog. conditions, recoveries of TBZ within the range 81.1-106.4{\%}, depending upon the sample, were obtained, with RSDs lower than 10{\%}. This novel method permits the unequivocal detn. of TBZ in the samples under study, according to the max. residue levels allowed within Europe, in less than 20 min and without any need for a clean-up step in the anal. protocol.",
keywords = "polymer microspheres , polymerization , thiabendazole",
author = "Francisco Barahona and Esther Turiel and Cormack, {Peter A. G.} and Antonio. Martin-Esteban",
year = "2011",
doi = "10.1002/jssc.201000277",
language = "Undefined/Unknown",
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pages = "217--224",
journal = "Journal of Separation Science",
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T1 - Synthesis of core-shell molecularly imprinted polymer microspheres by precipitation polymerization for the inline molecularly imprinted solid-phase extraction of thiabendazole from citrus fruits and orange juice samples

AU - Barahona, Francisco

AU - Turiel, Esther

AU - Cormack, Peter A. G.

AU - Martin-Esteban, Antonio.

PY - 2011

Y1 - 2011

N2 - In this work, the synthesis of molecularly imprinted polymer microspheres with narrow particle size distributions and core-shell morphol. by a two-step pptn. polymn. procedure is described. Polydivinylbenzene (poly DVB-80) core particles were used as seed particles in the prodn. of molecularly imprinted polymer shells by copolymn. of divinylbenzene-80 with methacrylic acid in the presence of thiabendazole (TBZ) and an appropriate porogen. Thereafter, polymer particles were packed into refillable stainless steel HPLC columns used in the development of an inline molecularly imprinted SPE method for the detn. of TBZ in citrus fruits and orange juice samples. Under optimized chromatog. conditions, recoveries of TBZ within the range 81.1-106.4%, depending upon the sample, were obtained, with RSDs lower than 10%. This novel method permits the unequivocal detn. of TBZ in the samples under study, according to the max. residue levels allowed within Europe, in less than 20 min and without any need for a clean-up step in the anal. protocol.

AB - In this work, the synthesis of molecularly imprinted polymer microspheres with narrow particle size distributions and core-shell morphol. by a two-step pptn. polymn. procedure is described. Polydivinylbenzene (poly DVB-80) core particles were used as seed particles in the prodn. of molecularly imprinted polymer shells by copolymn. of divinylbenzene-80 with methacrylic acid in the presence of thiabendazole (TBZ) and an appropriate porogen. Thereafter, polymer particles were packed into refillable stainless steel HPLC columns used in the development of an inline molecularly imprinted SPE method for the detn. of TBZ in citrus fruits and orange juice samples. Under optimized chromatog. conditions, recoveries of TBZ within the range 81.1-106.4%, depending upon the sample, were obtained, with RSDs lower than 10%. This novel method permits the unequivocal detn. of TBZ in the samples under study, according to the max. residue levels allowed within Europe, in less than 20 min and without any need for a clean-up step in the anal. protocol.

KW - polymer microspheres

KW - polymerization

KW - thiabendazole

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DO - 10.1002/jssc.201000277

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