Synthesis of cis,cis-diunsaturated α-meromycolic acid by a palladium-catalysed alkyl–alkyl Negishi reaction

Giacomo Berretta, Geoffrey Coxon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The first total synthesis of cis,cis-diunsaturated α-meromycolic acid has been accomplished using a convergent strategy and a palladium-catalysed alkyl–alkyl Negishi reaction as the key step.
Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number2
DOIs
Publication statusPublished - 11 Jan 2012

Keywords

  • fatty acids
  • Negishi reaction
  • synthesis
  • tuberculosis
  • drug discovery
  • mycolic acids
  • meromycolate

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