Abstract
A simple and effective method for the preparation of benzoxazolones from nitroarenes or aryl halides is described. Partial reduction of a nitro group in the presence of a chloroformate followed by a microwave assisted rearrangement/ring closure sequence provides a convenient and practical procedure to prepare this important pharmacophore. Rearrangement precursors were also accessed from aryl halides through transition-metal catalyzed coupling.
| Original language | English |
|---|---|
| Pages (from-to) | 812-815 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 19 Feb 2010 |
Keywords
- highly efficient nitration
- oxidative cyclocarbonylation
- betaaminoalcohols
- phenolic-compounds
- Palladium
- hydroxylamines
- 2-aminophenol
- carbonylation
- rearrangement
- iodides