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We report an optimised and highly efficient synthetic route towards a valuable functionalised fluorinated building block. The key-steps include difluorocyclopropanation of a disubstituted alkene with a suitable difluorocarbene precursor, and a radical-induced cyclopropane ring-opening, operating via an iodide atom transfer reaction.
- fluorinated building blocks
- difluorocyclopropane ring opening
FingerprintDive into the research topics of 'Synthesis of an allylic gem-difluoromethylene building block via radical-mediated difluorocyclopropane ring opening'. Together they form a unique fingerprint.
- 1 Active
PP: Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
1/01/19 → 31/12/23