Synthesis of an allylic gem-difluoromethylene building block via radical-mediated difluorocyclopropane ring opening

Research output: Contribution to journalArticlepeer-review

Abstract

We report an optimised and highly efficient synthetic route towards a valuable functionalised fluorinated building block. The key-steps include difluorocyclopropanation of a disubstituted alkene with a suitable difluorocarbene precursor, and a radical-induced cyclopropane ring-opening, operating via an iodide atom transfer reaction.
Original languageEnglish
Article number153344
Number of pages4
JournalTetrahedron Letters
Volume81
Early online date25 Aug 2021
DOIs
Publication statusPublished - 28 Sep 2021

Keywords

  • fluorinated building blocks
  • difluorocyclopropanation
  • difluorocyclopropane ring opening

Fingerprint

Dive into the research topics of 'Synthesis of an allylic gem-difluoromethylene building block via radical-mediated difluorocyclopropane ring opening'. Together they form a unique fingerprint.

Cite this