Synthesis of a new series of 1H-imidazol-1-yl substituted 8-phenylxanthines as adenosine receptor ligands

Ranju Bansal, Gulshan Kumar, Deepika Gandhi, Louise C Young, Alan L Harvey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new series of 1H-imidazol-1-yl substituted 8-phenylxanthine analogs has been synthesized to study the effects of the imidazole group on the binding affinity of compounds for adenosine receptors. Competition binding studies of these compounds were carried out in vitro with human cloned receptors using [(3) H]DPCPX and [(3) H]ZM 241385 as radioligands at A(1) and A(2A) adenosine receptors, respectively. The effect of the substitution pattern of the (imidazolyl)alkoxy group on various positions of the phenyl ring at C(8) was also studied. The xanthine derivatives displayed varying degrees of affinity and selectivity towards A(1) and A(2A) receptor subtypes despite a common but variedly substituted Ar-C(8).
Original languageEnglish
Pages (from-to)1290-1300
Number of pages11
JournalChemistry and Biodiversity
Volume8
Issue number7
Early online date18 Jul 2011
DOIs
Publication statusPublished - 2011

Keywords

  • xanthine derivatives
  • inhibitors
  • modulators
  • potent
  • affinity
  • antagonists

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