Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester

S.J. Yousouf, C.R. Brodie, N.J. Wheate, J.R. Aldrich-Wright

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A potential anticancer heterodinuclear ruthenium(II)-platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their -- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV-Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.
LanguageEnglish
Pages318-328
Number of pages10
JournalPolyhedron
Volume26
Issue number2
DOIs
Publication statusPublished - 2007

Fingerprint

Ruthenium
cysteine
Platinum
ruthenium
esters
Esters
platinum
synthesis
Cysteamine
Electrospray ionization
Column chromatography
Phenanthrolines
Dichroism
chromatography
Isomers
dichroism
Mass spectrometry
Cysteine
Chlorides
mass spectroscopy

Keywords

  • ruthenium(II)
  • platinum(II)
  • heterodinuclear
  • L-Cysteine methyl ester
  • phenanthroline
  • anticancer
  • pharmacological sciences

Cite this

Yousouf, S.J. ; Brodie, C.R. ; Wheate, N.J. ; Aldrich-Wright, J.R. / Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester. In: Polyhedron. 2007 ; Vol. 26, No. 2. pp. 318-328.
@article{6c8828b1a4ca4766a8f1c5dcf6691e3d,
title = "Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester",
abstract = "A potential anticancer heterodinuclear ruthenium(II)-platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their -- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV-Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.",
keywords = "ruthenium(II), platinum(II), heterodinuclear, L-Cysteine methyl ester, phenanthroline, anticancer, pharmacological sciences",
author = "S.J. Yousouf and C.R. Brodie and N.J. Wheate and J.R. Aldrich-Wright",
year = "2007",
doi = "10.1016/j.poly.2006.06.004",
language = "English",
volume = "26",
pages = "318--328",
journal = "Polyhedron",
issn = "0277-5387",
number = "2",

}

Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester. / Yousouf, S.J.; Brodie, C.R.; Wheate, N.J.; Aldrich-Wright, J.R.

In: Polyhedron, Vol. 26, No. 2, 2007, p. 318-328.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester

AU - Yousouf, S.J.

AU - Brodie, C.R.

AU - Wheate, N.J.

AU - Aldrich-Wright, J.R.

PY - 2007

Y1 - 2007

N2 - A potential anticancer heterodinuclear ruthenium(II)-platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their -- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV-Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

AB - A potential anticancer heterodinuclear ruthenium(II)-platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their -- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV-Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

KW - ruthenium(II)

KW - platinum(II)

KW - heterodinuclear

KW - L-Cysteine methyl ester

KW - phenanthroline

KW - anticancer

KW - pharmacological sciences

UR - http://dx.doi.org/10.1016/j.poly.2006.06.004

U2 - 10.1016/j.poly.2006.06.004

DO - 10.1016/j.poly.2006.06.004

M3 - Article

VL - 26

SP - 318

EP - 328

JO - Polyhedron

T2 - Polyhedron

JF - Polyhedron

SN - 0277-5387

IS - 2

ER -