Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The synthesis of a benzotriazole azo dye phosphoramidite and the subsequent use in solid phase synthesis of oligonucleotides is reported. The azo dye is shown as a surface enhanced resonance Raman label for oligonucleotides that is capable of immobilisation of the oligonucleotide on metal surfaces such as silver nanoparticles. (C) 2003 Elsevier Science Ltd. All rights reserved.
LanguageEnglish
Pages1339-1342
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number7
DOIs
Publication statusPublished - 10 Feb 2003

Fingerprint

Azo Compounds
Oligonucleotides
Labeling
Solid-Phase Synthesis Techniques
Silver
Immobilization
Nanoparticles
Labels
Metals
benzotriazole
phosphoramidite

Keywords

  • resonance raman-scattering
  • nanoparticle probes
  • dna
  • serrs

Cite this

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Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides. / Brown, R.; Smith, W.E.; Graham, D.

In: Tetrahedron Letters, Vol. 44, No. 7, 10.02.2003, p. 1339-1342.

Research output: Contribution to journalArticle

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AU - Brown, R.

AU - Smith, W.E.

AU - Graham, D.

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AB - The synthesis of a benzotriazole azo dye phosphoramidite and the subsequent use in solid phase synthesis of oligonucleotides is reported. The azo dye is shown as a surface enhanced resonance Raman label for oligonucleotides that is capable of immobilisation of the oligonucleotide on metal surfaces such as silver nanoparticles. (C) 2003 Elsevier Science Ltd. All rights reserved.

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KW - serrs

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