Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides

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Abstract

The synthesis of a benzotriazole azo dye phosphoramidite and the subsequent use in solid phase synthesis of oligonucleotides is reported. The azo dye is shown as a surface enhanced resonance Raman label for oligonucleotides that is capable of immobilisation of the oligonucleotide on metal surfaces such as silver nanoparticles. (C) 2003 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1339-1342
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number7
DOIs
Publication statusPublished - 10 Feb 2003

Keywords

  • resonance raman-scattering
  • nanoparticle probes
  • dna
  • serrs

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