The synthesis of a benzotriazole azo dye phosphoramidite and the subsequent use in solid phase synthesis of oligonucleotides is reported. The azo dye is shown as a surface enhanced resonance Raman label for oligonucleotides that is capable of immobilisation of the oligonucleotide on metal surfaces such as silver nanoparticles. (C) 2003 Elsevier Science Ltd. All rights reserved.
|Number of pages||3|
|Publication status||Published - 10 Feb 2003|
- resonance raman-scattering
- nanoparticle probes