Synthesis of 4-(Carbonyloxyphenyl)-1,4-dihydropyridines as potential antihypertensive agents

R. Bansal, G. Narang, C. Calle, R. Carron, K. Pemberton, A.L. Harvey

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Preclinical Research A series of novel symmetric and asymmetric 4-(carbonyloxyphenyl)-1,4-dihydropyridines (DHPs) was synthesized and evaluated for calcium channel blocking, vasodilatory and antihypertensive properties. Some of these new DHPs displayed potent calcium channel blocking and good vasodilatory activities. Heart rate remained relatively constant in comparison with blood pressure changes in the case of these newly synthesized compounds, thereby decreasing the probability of reflex tachycardia, a major side effect of nifedipine. The most potent compound, ethyl methyl 4-(3- isopropylcarbonyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (14c) exhibited antihypertensive activity comparable with the standard drug - nifedipine.
Original languageEnglish
Pages (from-to)50-61
Number of pages12
JournalDrug Development Research
Issue number1
Publication statusPublished - 1 Feb 2013


  • synthesis
  • 4-(Carbonyloxyphenyl)-1,4-dihydropyridines
  • antihypertensive agents


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