[3H]Genipin was synthesized in a single step by Ir(I) catalyzed hydrogen isotope exchange. Conditions for selective exchange of the sp2 CH bond ortho to the methyl ester functionality were developed through deuterium modeling studies through a catalyst screen. Optimized conditions so obtained were then utilized with tritium gas to generate [3H]genipin at a specific activity of 18.5 Ci/mmol. Racemic [14C]genipin was prepared in eight steps in overall 5.4% radiochemical yield from potassium [14C]cyanide.
|Number of pages||7|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Early online date||4 Feb 2020|
|Publication status||Published - 30 Apr 2020|
- gardenia blue
- Iridium (I)
- Otera's catalyst