Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2

Osama I. G. Khreit; Craig Irving; Elke Schmidt; John A. Parkinson; Niamh Nic Daeid; Oliver B. Sutcliffe

doi:10.1016/j.jpba.2011.11.004

Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2

Osama I. G. Khreit, Craig Irving, Elke Schmidt, John A. Parkinson, Niamh Nic Daeid, Oliver B. Sutcliffe

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

Original language	English
Pages (from-to)	122-135
Number of pages	14
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	61
DOIs	https://doi.org/10.1016/j.jpba.2011.11.004
Publication status	Published - 5 Mar 2012

Keywords

NRG-2
4-methylmethcathinone
mephedrone
drugs

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10.1016/j.jpba.2011.11.004

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Illicit drug analysis as a tool to combat global organised crime
Niamh Nic Daeid (Participant), David Littlejohn (Participant), William Kerr (Participant), Oliver Brook Sutcliffe (Participant), Katy Savage (Participant) & W. Meier-Augenstein (Participant)
Impact: Impact - for External Portal › Quality of life and safety, Economic and commerce, Professional practice, training and standards

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Khreit, O. I. G., Irving, C., Schmidt, E., Parkinson, J. A., Daeid, N. N., & Sutcliffe, O. B. (2012). Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2. Journal of Pharmaceutical and Biomedical Analysis, 61, 122-135. https://doi.org/10.1016/j.jpba.2011.11.004

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title = "Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2",

abstract = "The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.",

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author = "Khreit, {Osama I. G.} and Craig Irving and Elke Schmidt and Parkinson, {John A.} and Daeid, {Niamh Nic} and Sutcliffe, {Oliver B.}",

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doi = "10.1016/j.jpba.2011.11.004",

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Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2. / Khreit, Osama I. G.; Irving, Craig; Schmidt, Elke; Parkinson, John A.; Daeid, Niamh Nic; Sutcliffe, Oliver B.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 61, 05.03.2012, p. 122-135.

Research output: Contribution to journal › Article › peer-review

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T1 - Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2

AU - Khreit, Osama I. G.

AU - Irving, Craig

AU - Schmidt, Elke

AU - Parkinson, John A.

AU - Daeid, Niamh Nic

AU - Sutcliffe, Oliver B.

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AB - The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

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Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2

Abstract

Keywords

Access to Document

Illicit drug analysis as a tool to combat global organised crime

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