Abstract
The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.
| Language | English |
|---|---|
| Pages | 122-135 |
| Number of pages | 14 |
| Journal | Journal of Pharmaceutical and Biomedical Analysis |
| Volume | 61 |
| DOIs | |
| Publication status | Published - 5 Mar 2012 |
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Keywords
- NRG-2
- 4-methylmethcathinone
- mephedrone
- drugs
Cite this
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Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2. / Khreit, Osama I. G.; Irving, Craig; Schmidt, Elke; Parkinson, John A.; Daeid, Niamh Nic; Sutcliffe, Oliver B.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 61, 05.03.2012, p. 122-135.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2
AU - Khreit, Osama I. G.
AU - Irving, Craig
AU - Schmidt, Elke
AU - Parkinson, John A.
AU - Daeid, Niamh Nic
AU - Sutcliffe, Oliver B.
PY - 2012/3/5
Y1 - 2012/3/5
N2 - The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.
AB - The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.
KW - NRG-2
KW - 4-methylmethcathinone
KW - mephedrone
KW - drugs
UR - http://www.scopus.com/inward/record.url?scp=84856101009&partnerID=8YFLogxK
U2 - 10.1016/j.jpba.2011.11.004
DO - 10.1016/j.jpba.2011.11.004
M3 - Article
VL - 61
SP - 122
EP - 135
JO - Journal of Pharmaceutical and Biomedical Analysis
T2 - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
SN - 0731-7085
ER -