Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2

Osama I. G. Khreit, Craig Irving, Elke Schmidt, John A. Parkinson, Niamh Nic Daeid, Oliver B. Sutcliffe

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

Original languageEnglish
Pages (from-to)122-135
Number of pages14
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume61
DOIs
Publication statusPublished - 5 Mar 2012

Keywords

  • NRG-2
  • 4-methylmethcathinone
  • mephedrone
  • drugs

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  • Impacts

    Illicit drug analysis as a tool to combat global organised crime

    Niamh Nic Daeid (Participant), David Littlejohn (Participant), William Kerr (Participant), Oliver Brook Sutcliffe (Participant), Katy Savage (Participant) & W. Meier-Augenstein (Participant)

    Impact: Impact - for External PortalQuality of life and safety, Economic and commerce, Professional practice, training and standards

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