Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): a new "legal high"

Eman Y. Santali, Anna-Karina Cadogan, Niamh Nic Daeid, Kathleen A. Savage, Oliver B. Sutcliffe

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.

Original languageEnglish
Pages (from-to)246-255
Number of pages10
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume56
Issue number2
DOIs
Publication statusPublished - 10 Sep 2011

Keywords

  • Mephedrone
  • Cathinone
  • legal high
  • analytical profiling
  • HPLC
  • Methcathionoe
  • 4-Methlymethcathinone
  • toxicity

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