Synthesis, full chemical characterisation and development of validated methods for the quantification of  (±)-4′-methylmethcathinone (mephedrone): a new "legal high"

Eman Y. Santali; Anna-Karina Cadogan; Niamh Nic Daeid; Kathleen A. Savage; Oliver B. Sutcliffe

doi:10.1016/j.jpba.2011.05.022

Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): a new "legal high"

Eman Y. Santali, Anna-Karina Cadogan, Niamh Nic Daeid, Kathleen A. Savage, Oliver B. Sutcliffe

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.

Original language	English
Pages (from-to)	246-255
Number of pages	10
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/j.jpba.2011.05.022
Publication status	Published - 10 Sept 2011

Keywords

Mephedrone
Cathinone
legal high
analytical profiling
HPLC
Methcathionoe
4-Methlymethcathinone
toxicity

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10.1016/j.jpba.2011.05.022

Cite this

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title = "Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): a new {"}legal high{"}",

abstract = "The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.",

keywords = "Mephedrone, Cathinone, legal high, analytical profiling, HPLC, Methcathionoe , 4-Methlymethcathinone, toxicity",

author = "Santali, {Eman Y.} and Anna-Karina Cadogan and Daeid, {Niamh Nic} and Savage, {Kathleen A.} and Sutcliffe, {Oliver B.}",

year = "2011",

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day = "10",

doi = "10.1016/j.jpba.2011.05.022",

language = "English",

volume = "56",

pages = "246--255",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

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publisher = "Elsevier B.V.",

number = "2",

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Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): a new "legal high". / Santali, Eman Y.; Cadogan, Anna-Karina; Daeid, Niamh Nic et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 56, No. 2, 10.09.2011, p. 246-255.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone)

T2 - a new "legal high"

AU - Santali, Eman Y.

AU - Cadogan, Anna-Karina

AU - Daeid, Niamh Nic

AU - Savage, Kathleen A.

AU - Sutcliffe, Oliver B.

PY - 2011/9/10

Y1 - 2011/9/10

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AB - The recent global increase in the abuse of 4'-methylmethcathinone and related compounds has developed a requirement for full chemical characterisation of these products. In this work we present full synthetic and chemical characterisation data and supplemental information for mephedrone synthesised as both the hydrobromide and hydrochloride salt. Additionally we report the first fully validated chromatographic methods for the detection and quantitative analysis of the substance both in its pure form and in the presence of a number of common adulterants used in illicit drug manufacture.

KW - Mephedrone

KW - Cathinone

KW - legal high

KW - analytical profiling

KW - HPLC

KW - Methcathionoe

KW - 4-Methlymethcathinone

KW - toxicity

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DO - 10.1016/j.jpba.2011.05.022

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SN - 0731-7085

VL - 56

SP - 246

EP - 255

JO - Journal of Pharmaceutical and Biomedical Analysis

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Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): a new "legal high"

Abstract

Keywords

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Illicit drug analysis as a tool to combat global organised crime

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Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): a new "legal high"

Abstract

Keywords

Access to Document

Other files and links

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Impacts

Illicit drug analysis as a tool to combat global organised crime

Cite this