Abstract
1,1,1-Trihaloalkanes of the types R-CCl2I, R-CClBrI, and R-CBr2I belonging to 1,1,1-trihalo-1-deoxy-d-arabinitol series of alditols were prepared and fully characterized by anomeric alkoxyl radical fragmentation of the corresponding 2,2-dihalo-2-deoxy-d-arabino-hexopyranose derivatives. The analogous diiodohalo compounds R-CClI2 and R-CBrI2 could not be prepared by this methodology. The results strongly suggest that the stability of the mixed trihalo alditols decreases with increasing bulkiness of the halogen atoms.
Original language | English |
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Pages (from-to) | 35-38 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2 Jan 2006 |
Keywords
- stability
- nonfluorinated
- trihalo-alkanes