Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives

D.P. Jindal, P. Piplani, H. Fajrak, C.B. Prior, I.G. Marshall

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The synthesis and pharmacological profiles of some new steroidal mono- and bisquaternary ammonium derivatives have been described. The compounds featured have been conceptually derived structurally from two lead structures: pancuronium bromide 1 and chandonium iodide 2. In vitro and in vivo neuromuscular blocking studies have indicated the monoquaternary compound 15 to be less active than the bisquaternary compounds 10 and 11. The compound 11 has been found to be more active than d-tubocurarine.
Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2001

Keywords

  • monoquaternary
  • bisquaternary
  • piperidine
  • chick biventer
  • anaesthetized cat
  • carbachol
  • nondepolarizing
  • steroidal

Fingerprint Dive into the research topics of 'Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives'. Together they form a unique fingerprint.

Cite this