Synthesis and neuromuscular blocking activity of 16β-piperidino epiandrosterone derivatives

Sonal Dubey; D.P. Jindal; Poonam Piplani; Louse C. Young; Behrooz Fathi; Alan L. Harvey

doi:10.1007/s00044-005-0136-9

Synthesis and neuromuscular blocking activity of 16β-piperidino epiandrosterone derivatives

Sonal Dubey, D.P. Jindal, Poonam Piplani^*, Louse C. Young, Behrooz Fathi, Alan L. Harvey

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy function for potent antagonist activity.

Original language	English
Pages (from-to)	229-240
Number of pages	12
Journal	Medicinal Chemistry Research
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/s00044-005-0136-9
Publication status	Published - 30 Jun 2005

Keywords

nitrogen
ammonium
steroid
nerve simulation
quaternary ammonium

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10.1007/s00044-005-0136-9

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title = "Synthesis and neuromuscular blocking activity of 16β-piperidino epiandrosterone derivatives",

abstract = "This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy function for potent antagonist activity.",

keywords = "nitrogen, ammonium, steroid, nerve simulation, quaternary ammonium",

author = "Sonal Dubey and D.P. Jindal and Poonam Piplani and Young, {Louse C.} and Behrooz Fathi and Harvey, {Alan L.}",

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T1 - Synthesis and neuromuscular blocking activity of 16β-piperidino epiandrosterone derivatives

AU - Dubey, Sonal

AU - Jindal, D.P.

AU - Piplani, Poonam

AU - Young, Louse C.

AU - Fathi, Behrooz

AU - Harvey, Alan L.

PY - 2005/6/30

Y1 - 2005/6/30

N2 - This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy function for potent antagonist activity.

AB - This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy function for potent antagonist activity.

KW - nitrogen

KW - ammonium

KW - steroid

KW - nerve simulation

KW - quaternary ammonium

UR - http://www.scopus.com/inward/record.url?scp=33747132652&partnerID=8YFLogxK

UR - https://link.springer.com/journal/44

U2 - 10.1007/s00044-005-0136-9

DO - 10.1007/s00044-005-0136-9

M3 - Article

AN - SCOPUS:33747132652

SN - 1054-2523

VL - 14

SP - 229

EP - 240

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 4

ER -

Synthesis and neuromuscular blocking activity of 16β-piperidino epiandrosterone derivatives

Abstract

Keywords

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