Synthesis and neuromuscular blocking activity of 16β-piperidino epiandrosterone derivatives

Sonal Dubey, D.P. Jindal, Poonam Piplani, Louse C. Young, Behrooz Fathi, Alan L. Harvey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy function for potent antagonist activity.

Original languageEnglish
Pages (from-to)229-240
Number of pages12
JournalMedicinal Chemistry Research
Volume14
Issue number4
DOIs
Publication statusPublished - 30 Jun 2005

Keywords

  • nitrogen
  • ammonium
  • steroid
  • nerve simulation
  • quaternary ammonium

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