Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Vânia M. A. Moreira, Tadas S. Vasaitis, Vincent C. O. Njar, Jorge A. R. Salvador

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17alpha-hydroxylase-C(17,20)-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.

Original languageEnglish
Pages (from-to)939-948
Number of pages10
JournalSteroids
Volume72
Issue number14
Early online date15 Aug 2007
DOIs
Publication statusPublished - 31 Dec 2007

Keywords

  • binding, competitive
  • cell line, tumor
  • cell proliferation
  • dehydroepiandrosterone

Fingerprint Dive into the research topics of 'Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors'. Together they form a unique fingerprint.

  • Cite this