Synthesis and characterization of water-soluble densely branched glycopolymers

P. Besenius, S. Slavin, F. Vilela, D.C. Sherrington

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In a one-pot synthesis, highly branched synthetic glycopolymers have been prepared using the 'Strathclyde Methodology' involving a protected galactose monomethacrylate, a branching comonomer (ethylene glycol dimethacrylate or divinylbenzene) and a chain transfer agent (dodecanethiol) with 2,2′-azo-bis-isobutyronitrile as the source of radicals. Branching was confirmed via MALS/SEC and 1H NMR spectroscopy. One attractive feature of the methodology employed is that in a single-step procedure highly branched polymers with molar masses over a range of two orders of magnitude were obtained by fine-tuning the composition of comonomer and chain transfer agent mole feed ratio. Deprotection of the isopropylidene galactose functionalities on the polymers was achieved, leading to water-soluble and potentially bio-compatible synthetic glycopolymers with branched main chain architecture.
LanguageEnglish
Pages1524-1533
Number of pages9
JournalReactive and Functional Polymers
Volume68
Issue number11
DOIs
Publication statusPublished - Nov 2008

Fingerprint

divinyl benzene
Galactose
Polymers
polymer
methodology
Water
Molar mass
Ethylene glycol
ethylene
Nuclear magnetic resonance spectroscopy
nuclear magnetic resonance
Magnetic Resonance Spectroscopy
Tuning
spectroscopy
water
Chemical analysis
isobutyronitrile
propylene
ethylene dimethacrylate
Proton Magnetic Resonance Spectroscopy

Keywords

  • conventional free-radical polymerisation
  • branched architecture
  • glycopolymer
  • water-soluble copolymers
  • facile synthesis

Cite this

Besenius, P. ; Slavin, S. ; Vilela, F. ; Sherrington, D.C. / Synthesis and characterization of water-soluble densely branched glycopolymers. In: Reactive and Functional Polymers. 2008 ; Vol. 68, No. 11. pp. 1524-1533.
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Synthesis and characterization of water-soluble densely branched glycopolymers. / Besenius, P.; Slavin, S.; Vilela, F.; Sherrington, D.C.

In: Reactive and Functional Polymers, Vol. 68, No. 11, 11.2008, p. 1524-1533.

Research output: Contribution to journalArticle

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T1 - Synthesis and characterization of water-soluble densely branched glycopolymers

AU - Besenius, P.

AU - Slavin, S.

AU - Vilela, F.

AU - Sherrington, D.C.

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AB - In a one-pot synthesis, highly branched synthetic glycopolymers have been prepared using the 'Strathclyde Methodology' involving a protected galactose monomethacrylate, a branching comonomer (ethylene glycol dimethacrylate or divinylbenzene) and a chain transfer agent (dodecanethiol) with 2,2′-azo-bis-isobutyronitrile as the source of radicals. Branching was confirmed via MALS/SEC and 1H NMR spectroscopy. One attractive feature of the methodology employed is that in a single-step procedure highly branched polymers with molar masses over a range of two orders of magnitude were obtained by fine-tuning the composition of comonomer and chain transfer agent mole feed ratio. Deprotection of the isopropylidene galactose functionalities on the polymers was achieved, leading to water-soluble and potentially bio-compatible synthetic glycopolymers with branched main chain architecture.

KW - conventional free-radical polymerisation

KW - branched architecture

KW - glycopolymer

KW - water-soluble copolymers

KW - facile synthesis

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