Synthesis and characterization of micrometer-sized molecularly imprinted spherical polymer particulates prepared via precipitation polymerization

Peter Cormack, J.F. Wang, P.A.G. Cormack, D.C. Sherrington and E. Khoshdel

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In this paper, the synthesis and characterization of molecularly imprinted spherical polymer particulates prepared via precipitation polymerization is described. The effects of the monomer and initiator concentrations and the solvent on the polymerizations were investigated systematically. Polymer microspheres with narrow size distributions and average diameters up to ca. 10 μm were prepared under optimized polymerization conditions. The morphologies of the microspheres were characterized by nitrogen sorption porosimetry and the molecular recognition properties of representative products evaluated in high-performance liquid chromatography (HPLC) mode. Imprinting effects were confirmed by analyzing the relative retentions of the analytes on imprinted and non-imprinted packed HPLC columns. Finally, two different agitation/mixing methods for precipitation polymerizations were compared. It was found that the use of a low-profile roller housed inside a temperature-controlled incubator had advantages over a rotavapor-based system. Overall, this study has served to highlight the attractiveness of precipitation polymerization for the routine production of molecularly imprinted polymers in a well-defined spherical particulate form via an efficient one-step synthetic process.
LanguageEnglish
Pages1505-1519
Number of pages15
JournalPure and Applied Chemistry
Volume79
Issue number9
DOIs
Publication statusPublished - 2007

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Polymers
Polymerization
High performance liquid chromatography
Microspheres
Molecular recognition
Sorption
Nitrogen
Monomers
Temperature

Keywords

  • HPLC
  • xanthines
  • molecular imprinting
  • precipitation polymerization
  • particle synthesis

Cite this

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abstract = "In this paper, the synthesis and characterization of molecularly imprinted spherical polymer particulates prepared via precipitation polymerization is described. The effects of the monomer and initiator concentrations and the solvent on the polymerizations were investigated systematically. Polymer microspheres with narrow size distributions and average diameters up to ca. 10 μm were prepared under optimized polymerization conditions. The morphologies of the microspheres were characterized by nitrogen sorption porosimetry and the molecular recognition properties of representative products evaluated in high-performance liquid chromatography (HPLC) mode. Imprinting effects were confirmed by analyzing the relative retentions of the analytes on imprinted and non-imprinted packed HPLC columns. Finally, two different agitation/mixing methods for precipitation polymerizations were compared. It was found that the use of a low-profile roller housed inside a temperature-controlled incubator had advantages over a rotavapor-based system. Overall, this study has served to highlight the attractiveness of precipitation polymerization for the routine production of molecularly imprinted polymers in a well-defined spherical particulate form via an efficient one-step synthetic process.",
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Synthesis and characterization of micrometer-sized molecularly imprinted spherical polymer particulates prepared via precipitation polymerization. / J.F. Wang, P.A.G. Cormack, D.C. Sherrington and E. Khoshdel.

In: Pure and Applied Chemistry, Vol. 79, No. 9, 2007, p. 1505-1519.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and characterization of micrometer-sized molecularly imprinted spherical polymer particulates prepared via precipitation polymerization

AU - Cormack, Peter

AU - J.F. Wang, P.A.G. Cormack, D.C. Sherrington and E. Khoshdel

PY - 2007

Y1 - 2007

N2 - In this paper, the synthesis and characterization of molecularly imprinted spherical polymer particulates prepared via precipitation polymerization is described. The effects of the monomer and initiator concentrations and the solvent on the polymerizations were investigated systematically. Polymer microspheres with narrow size distributions and average diameters up to ca. 10 μm were prepared under optimized polymerization conditions. The morphologies of the microspheres were characterized by nitrogen sorption porosimetry and the molecular recognition properties of representative products evaluated in high-performance liquid chromatography (HPLC) mode. Imprinting effects were confirmed by analyzing the relative retentions of the analytes on imprinted and non-imprinted packed HPLC columns. Finally, two different agitation/mixing methods for precipitation polymerizations were compared. It was found that the use of a low-profile roller housed inside a temperature-controlled incubator had advantages over a rotavapor-based system. Overall, this study has served to highlight the attractiveness of precipitation polymerization for the routine production of molecularly imprinted polymers in a well-defined spherical particulate form via an efficient one-step synthetic process.

AB - In this paper, the synthesis and characterization of molecularly imprinted spherical polymer particulates prepared via precipitation polymerization is described. The effects of the monomer and initiator concentrations and the solvent on the polymerizations were investigated systematically. Polymer microspheres with narrow size distributions and average diameters up to ca. 10 μm were prepared under optimized polymerization conditions. The morphologies of the microspheres were characterized by nitrogen sorption porosimetry and the molecular recognition properties of representative products evaluated in high-performance liquid chromatography (HPLC) mode. Imprinting effects were confirmed by analyzing the relative retentions of the analytes on imprinted and non-imprinted packed HPLC columns. Finally, two different agitation/mixing methods for precipitation polymerizations were compared. It was found that the use of a low-profile roller housed inside a temperature-controlled incubator had advantages over a rotavapor-based system. Overall, this study has served to highlight the attractiveness of precipitation polymerization for the routine production of molecularly imprinted polymers in a well-defined spherical particulate form via an efficient one-step synthetic process.

KW - HPLC

KW - xanthines

KW - molecular imprinting

KW - precipitation polymerization

KW - particle synthesis

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