Abstract
| Language | English |
|---|---|
| Pages | 6-11 |
| Number of pages | 6 |
| Journal | Analytica Chimica Acta |
| Volume | 597 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 30 Jul 2007 |
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Keywords
- molecularly imprinted polymer
- carbamazepine
- solid-phase extraction
- urine samples
- wastewater
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Synthesis and application of a carbamazepine imprinted polymer for solid-phase extraction from urine and waste water. / Beltran, A.; Caro, E.; Marcé, R.M.; Cormack, P.A.G.; Sherrington, D.C.; Borrull, F.
In: Analytica Chimica Acta, Vol. 597, No. 1, 30.07.2007, p. 6-11.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis and application of a carbamazepine imprinted polymer for solid-phase extraction from urine and waste water
AU - Beltran, A.
AU - Caro, E.
AU - Marcé, R.M.
AU - Cormack, P.A.G.
AU - Sherrington, D.C.
AU - Borrull, F.
PY - 2007/7/30
Y1 - 2007/7/30
N2 - A molecularly imprinted polymer (MIP) designed to enable the selective extraction of carbamazepine (CBZ) from effluent wastewater and urine samples has been synthesised using a non-covalent molecular imprinting approach. The MIP was evaluated chromatographically in the first instance and its affinity for CBZ also confirmed by solid-phase extraction (SPE). The optimal conditions for SPE consisted of conditioning of the cartridge using acidified water purified from a Milli-Q system, loading of the sample under basic aqueous conditions, clean-up using acetonitrile and elution with methanol. The attractive molecular recognition properties of the MIP gave rise to good CBZ recoveries (80%) when 100 mL of effluent water spiked with 1 μg L−1 was percolated through the polymer. For urine samples, 2 mL samples spiked with 2.5 μg L−1 CBZ were extracted with a recovery of 65%. For urine, the linear range was 0.05–24 mg L−1, the limit of detection was 25 μg L−1 and precision, expressed as relative standard deviation at 0.5 mg L−1 (n = 3), was 3.1% and 12.6% for repeatability and reproducibility between days, respectively.
AB - A molecularly imprinted polymer (MIP) designed to enable the selective extraction of carbamazepine (CBZ) from effluent wastewater and urine samples has been synthesised using a non-covalent molecular imprinting approach. The MIP was evaluated chromatographically in the first instance and its affinity for CBZ also confirmed by solid-phase extraction (SPE). The optimal conditions for SPE consisted of conditioning of the cartridge using acidified water purified from a Milli-Q system, loading of the sample under basic aqueous conditions, clean-up using acetonitrile and elution with methanol. The attractive molecular recognition properties of the MIP gave rise to good CBZ recoveries (80%) when 100 mL of effluent water spiked with 1 μg L−1 was percolated through the polymer. For urine samples, 2 mL samples spiked with 2.5 μg L−1 CBZ were extracted with a recovery of 65%. For urine, the linear range was 0.05–24 mg L−1, the limit of detection was 25 μg L−1 and precision, expressed as relative standard deviation at 0.5 mg L−1 (n = 3), was 3.1% and 12.6% for repeatability and reproducibility between days, respectively.
KW - molecularly imprinted polymer
KW - carbamazepine
KW - solid-phase extraction
KW - urine samples
KW - wastewater
U2 - 10.1016/j.aca.2007.06.040
DO - 10.1016/j.aca.2007.06.040
M3 - Article
VL - 597
SP - 6
EP - 11
JO - Analytica Chimica Acta
T2 - Analytica Chimica Acta
JF - Analytica Chimica Acta
SN - 0003-2670
IS - 1
ER -