Synthesis and anti-proliferative activity of sulfanyltriazolylnaphthalenols and sulfanyltriazolylnaphthalene-1,4-diones

Ibrahim Chaaban, El Sayeda M. El Khawass, Heba A. Abd El Razik, Nehad S. El Salamouni, Mariano Redondo-Horcajo, Isabel Barasoain, José Fernando Díaz, Jari Yli-Kauhaluoma, Vânia M. Moreira

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4 Citations (Scopus)

Abstract

A series of new sulfanyltriazolylnaphthalenols (10a-f and 13a-f) and sulfanyltriazolylnaphthalene-1,4-diones (14a-f) were synthesized and evaluated against a panel of cancer cell lines. Among the tested compounds, 10b and 10d showed the best anti-proliferative activity with GI(50) values ranging from 2.72 to 10 and 3.13 to 13.1 mu M, respectively, in several of the tumor cell lines tested. Compound 10d is highly selective toward leukemia cell lines and can be regarded as a good model for the development of new anti-leukemic agents.
Original languageEnglish
Pages (from-to)749-761
Number of pages13
JournalArchiv der Pharmazie
Volume349
Issue number9
Early online date12 Jul 2016
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • cancer
  • leukemia
  • quinone
  • sulfanyltriazolylnaphthalenols
  • synthesis
  • tumor-cell lines
  • anticancer agents
  • 1,2,4-triazole derivatives
  • biological evaluation
  • antitumor activity
  • acid synthesis
  • inhibitors
  • binding
  • imidazole
  • hydrazide

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    Chaaban, I., El Khawass, E. S. M., Abd El Razik, H. A., El Salamouni, N. S., Redondo-Horcajo, M., Barasoain, I., ... Moreira, V. M. (2016). Synthesis and anti-proliferative activity of sulfanyltriazolylnaphthalenols and sulfanyltriazolylnaphthalene-1,4-diones. Archiv der Pharmazie, 349(9), 749-761. https://doi.org/10.1002/ardp.201600134