Syntaxin 16 is a master recruitment factor for cytokinesis

Hélia Neto, Alexandra Kaupisch, Louise L. Collins, Gwyn W. Gould

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Abstract

Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleimide- sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome-associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked.

Original languageEnglish
Pages (from-to)3663-3674
Number of pages12
JournalMolecular Biology of the Cell
Volume24
Issue number23
DOIs
Publication statusPublished - 1 Dec 2013

Keywords

  • cytokinesis
  • intracellular organelles
  • SNARE
  • membrane traffic

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