Synaptic plasticity in the subiculum

Joachim Behr; Christian Wozny; Pawel Fidzinski; Dietmar Schmitz

doi:10.1016/j.pneurobio.2009.09.002

Synaptic plasticity in the subiculum

Joachim Behr, Christian Wozny, Pawel Fidzinski, Dietmar Schmitz

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

30 Citations (Scopus)

Abstract

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

Original language	English
Pages (from-to)	334-342
Number of pages	9
Journal	Progress in Neurobiology
Volume	89
Issue number	4
DOIs	https://doi.org/10.1016/j.pneurobio.2009.09.002
Publication status	Published - 10 Dec 2009

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Keywords

action potentials
animals
cerebral cortex
hippocampus
humans
learning
models, biological
neural pathways
neuronal plasticity
pyramidal cells
signal transduction
synapses

Cite this

Behr, J., Wozny, C., Fidzinski, P., & Schmitz, D. (2009). Synaptic plasticity in the subiculum. Progress in Neurobiology, 89(4), 334-342. https://doi.org/10.1016/j.pneurobio.2009.09.002

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KW - animals

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KW - hippocampus

KW - humans

KW - learning

KW - models, biological

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KW - signal transduction

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10.1016/j.pneurobio.2009.09.002