Synaptic plasticity in the subiculum

Joachim Behr, Christian Wozny, Pawel Fidzinski, Dietmar Schmitz

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

LanguageEnglish
Pages334-342
Number of pages9
JournalProgress in Neurobiology
Volume89
Issue number4
DOIs
Publication statusPublished - 10 Dec 2009

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Hippocampus
Pyramidal Cells
Synapses
Long-Term Memory

Keywords

  • action potentials
  • animals
  • cerebral cortex
  • hippocampus
  • humans
  • learning
  • models, biological
  • neural pathways
  • neuronal plasticity
  • pyramidal cells
  • signal transduction
  • synapses

Cite this

Behr, Joachim ; Wozny, Christian ; Fidzinski, Pawel ; Schmitz, Dietmar. / Synaptic plasticity in the subiculum. In: Progress in Neurobiology. 2009 ; Vol. 89, No. 4. pp. 334-342.
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Synaptic plasticity in the subiculum. / Behr, Joachim; Wozny, Christian; Fidzinski, Pawel; Schmitz, Dietmar.

In: Progress in Neurobiology, Vol. 89, No. 4, 10.12.2009, p. 334-342.

Research output: Contribution to journalArticle

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KW - animals

KW - cerebral cortex

KW - hippocampus

KW - humans

KW - learning

KW - models, biological

KW - neural pathways

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