Synaptic plasticity in the subiculum

Joachim Behr, Christian Wozny, Pawel Fidzinski, Dietmar Schmitz

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

Original languageEnglish
Pages (from-to)334-342
Number of pages9
JournalProgress in Neurobiology
Volume89
Issue number4
DOIs
Publication statusPublished - 10 Dec 2009

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Keywords

  • action potentials
  • animals
  • cerebral cortex
  • hippocampus
  • humans
  • learning
  • models, biological
  • neural pathways
  • neuronal plasticity
  • pyramidal cells
  • signal transduction
  • synapses

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