Abstract
The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
| Language | English |
|---|---|
| Pages | 334-342 |
| Number of pages | 9 |
| Journal | Progress in Neurobiology |
| Volume | 89 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 10 Dec 2009 |
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Keywords
- action potentials
- animals
- cerebral cortex
- hippocampus
- humans
- learning
- models, biological
- neural pathways
- neuronal plasticity
- pyramidal cells
- signal transduction
- synapses
Cite this
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Synaptic plasticity in the subiculum. / Behr, Joachim; Wozny, Christian; Fidzinski, Pawel; Schmitz, Dietmar.
In: Progress in Neurobiology, Vol. 89, No. 4, 10.12.2009, p. 334-342.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synaptic plasticity in the subiculum
AU - Behr, Joachim
AU - Wozny, Christian
AU - Fidzinski, Pawel
AU - Schmitz, Dietmar
PY - 2009/12/10
Y1 - 2009/12/10
N2 - The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
AB - The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
KW - action potentials
KW - animals
KW - cerebral cortex
KW - hippocampus
KW - humans
KW - learning
KW - models, biological
KW - neural pathways
KW - neuronal plasticity
KW - pyramidal cells
KW - signal transduction
KW - synapses
U2 - 10.1016/j.pneurobio.2009.09.002
DO - 10.1016/j.pneurobio.2009.09.002
M3 - Article
VL - 89
SP - 334
EP - 342
JO - Progress in Neurobiology
T2 - Progress in Neurobiology
JF - Progress in Neurobiology
SN - 0301-0082
IS - 4
ER -