Abstract
The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
Original language | English |
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Pages (from-to) | 334-342 |
Number of pages | 9 |
Journal | Progress in Neurobiology |
Volume | 89 |
Issue number | 4 |
DOIs | |
Publication status | Published - 10 Dec 2009 |
Keywords
- action potentials
- animals
- cerebral cortex
- hippocampus
- humans
- learning
- models, biological
- neural pathways
- neuronal plasticity
- pyramidal cells
- signal transduction
- synapses