Synaptic plasticity in the subiculum

Joachim Behr; Christian Wozny; Pawel Fidzinski; Dietmar Schmitz

doi:10.1016/j.pneurobio.2009.09.002

Synaptic plasticity in the subiculum

Joachim Behr, Christian Wozny, Pawel Fidzinski, Dietmar Schmitz

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

Original language	English
Pages (from-to)	334-342
Number of pages	9
Journal	Progress in Neurobiology
Volume	89
Issue number	4
DOIs	https://doi.org/10.1016/j.pneurobio.2009.09.002
Publication status	Published - 10 Dec 2009

Keywords

action potentials
animals
cerebral cortex
hippocampus
humans
learning
models, biological
neural pathways
neuronal plasticity
pyramidal cells
signal transduction
synapses

Access to Document

10.1016/j.pneurobio.2009.09.002

Cite this

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title = "Synaptic plasticity in the subiculum",

abstract = "The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.",

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AU - Behr, Joachim

AU - Wozny, Christian

AU - Fidzinski, Pawel

AU - Schmitz, Dietmar

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N2 - The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

AB - The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

KW - action potentials

KW - animals

KW - cerebral cortex

KW - hippocampus

KW - humans

KW - learning

KW - models, biological

KW - neural pathways

KW - neuronal plasticity

KW - pyramidal cells

KW - signal transduction

KW - synapses

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DO - 10.1016/j.pneurobio.2009.09.002

M3 - Article

C2 - 19770022

VL - 89

SP - 334

EP - 342

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

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