Swinhoeiamide A, a new highly active calyculin derivative from the marine sponge Theonella swinhoei

Ruangelie Edrada-Ebel, Rainer Ebel, Agus Supriyono, Victor Wray, Peter Schupp, Klaus Steube, Rob van Soest, Peter Proksch

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38 Citations (Scopus)


Analysis of the Papua New Guinean sponge Theonella swinhoei afforded a new calyculinamide-related congener for which we propose the name swinhoeiamide A (1). The structure of the new compound was unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, HMBC) and mass spectrometric (FABMS) data. Swinhoeiamide A exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated in an artificial diet offered to the larvae in a chronic feeding bioassay (ED(50) 2.11 ppm, LD(50) 2.98 ppm). Furthermore, it was found to be fungicidal against Candida albicans and Aspergillus fumigatus (MIC 1.2 and 1.0 microg/mL, respectively).

Original languageEnglish
Pages (from-to)1168-1172
Number of pages5
JournalJournal of Natural Products
Issue number8
Publication statusPublished - Aug 2002


  • animals
  • antifungal agents
  • aspergillus fumigatus
  • candida albicans
  • chromatography, high pressure liquid
  • feeding behavior
  • insecticides
  • larva
  • molecular structure
  • organophosphates
  • oxazoles
  • Papua New Guinea
  • porifera
  • spectrophotometry, ultraviolet
  • spodoptera
  • fungal spores


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