Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel

Maria Lucia Briuglia, Andrew Urquhart, Dimitrios Lamprou

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Materials which undergo self-assembly to form supermolecular structures can provide alternative strategies to drug loading problems in controlled release application. RADA 16 is a simple and versatile self-assembling peptide with a designed structure formed of two distinct surfaces, one hydrophilic and one hydrophobic that are positioned such a well-ordered fashion allowing precise assembly into a predetermined organization. A “smart” architecture in nanostructures can represent a good opportunity to use RADA16 as a carrier system for hydrophobic drugs solving problems of drugs delivery. In this work, we have investigated the diffusion properties of Pindolol, Quinine and Timolol Maleate from RADA16 in PBS and in BSS-PLUS at 37 °C. A sustained, controlled, reproducible and efficient drug release has been detected for all the systems, which has allow to understand the dependence of release kinetics on the physicochemical characteristics of RADA16 structural and chemical properties of the selected drugs and the nature of solvents used. For the analysis various physicochemical characterization techniques were used in order to investigate the state of the peptide before and after the drugs were added. Not only does RADA16 optimise drug performance, but it can also provide a solution for drug delivery issues associated with lipophilic drugs.
LanguageEnglish
Pages103–111
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume474
Issue number1-2
Early online date20 Aug 2014
DOIs
Publication statusPublished - 20 Oct 2014

Fingerprint

Hydrogel
Peptides
Pharmaceutical Preparations
Pindolol
Timolol
Quinine
Drug Liberation
Nanostructures

Keywords

  • controlled release
  • amphiphilic hydrogels
  • spectroscopy
  • AFM
  • lipophilic drugs

Cite this

Briuglia, Maria Lucia ; Urquhart, Andrew ; Lamprou, Dimitrios. / Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel. In: International Journal of Pharmaceutics. 2014 ; Vol. 474, No. 1-2. pp. 103–111.
@article{4e0fea6ed56d439f981175a57afe3db7,
title = "Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel",
abstract = "Materials which undergo self-assembly to form supermolecular structures can provide alternative strategies to drug loading problems in controlled release application. RADA 16 is a simple and versatile self-assembling peptide with a designed structure formed of two distinct surfaces, one hydrophilic and one hydrophobic that are positioned such a well-ordered fashion allowing precise assembly into a predetermined organization. A “smart” architecture in nanostructures can represent a good opportunity to use RADA16 as a carrier system for hydrophobic drugs solving problems of drugs delivery. In this work, we have investigated the diffusion properties of Pindolol, Quinine and Timolol Maleate from RADA16 in PBS and in BSS-PLUS at 37 °C. A sustained, controlled, reproducible and efficient drug release has been detected for all the systems, which has allow to understand the dependence of release kinetics on the physicochemical characteristics of RADA16 structural and chemical properties of the selected drugs and the nature of solvents used. For the analysis various physicochemical characterization techniques were used in order to investigate the state of the peptide before and after the drugs were added. Not only does RADA16 optimise drug performance, but it can also provide a solution for drug delivery issues associated with lipophilic drugs.",
keywords = "controlled release, amphiphilic hydrogels, spectroscopy, AFM, lipophilic drugs",
author = "Briuglia, {Maria Lucia} and Andrew Urquhart and Dimitrios Lamprou",
note = ". “NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, [VOL 474, ISSUE 1-2, (20/08/2014)] DOI:10.1016/j.ijpharm.2014.08.025",
year = "2014",
month = "10",
day = "20",
doi = "10.1016/j.ijpharm.2014.08.025",
language = "English",
volume = "474",
pages = "103–111",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
number = "1-2",

}

Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel. / Briuglia, Maria Lucia; Urquhart, Andrew; Lamprou, Dimitrios.

In: International Journal of Pharmaceutics, Vol. 474, No. 1-2, 20.10.2014, p. 103–111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel

AU - Briuglia, Maria Lucia

AU - Urquhart, Andrew

AU - Lamprou, Dimitrios

N1 - . “NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, [VOL 474, ISSUE 1-2, (20/08/2014)] DOI:10.1016/j.ijpharm.2014.08.025

PY - 2014/10/20

Y1 - 2014/10/20

N2 - Materials which undergo self-assembly to form supermolecular structures can provide alternative strategies to drug loading problems in controlled release application. RADA 16 is a simple and versatile self-assembling peptide with a designed structure formed of two distinct surfaces, one hydrophilic and one hydrophobic that are positioned such a well-ordered fashion allowing precise assembly into a predetermined organization. A “smart” architecture in nanostructures can represent a good opportunity to use RADA16 as a carrier system for hydrophobic drugs solving problems of drugs delivery. In this work, we have investigated the diffusion properties of Pindolol, Quinine and Timolol Maleate from RADA16 in PBS and in BSS-PLUS at 37 °C. A sustained, controlled, reproducible and efficient drug release has been detected for all the systems, which has allow to understand the dependence of release kinetics on the physicochemical characteristics of RADA16 structural and chemical properties of the selected drugs and the nature of solvents used. For the analysis various physicochemical characterization techniques were used in order to investigate the state of the peptide before and after the drugs were added. Not only does RADA16 optimise drug performance, but it can also provide a solution for drug delivery issues associated with lipophilic drugs.

AB - Materials which undergo self-assembly to form supermolecular structures can provide alternative strategies to drug loading problems in controlled release application. RADA 16 is a simple and versatile self-assembling peptide with a designed structure formed of two distinct surfaces, one hydrophilic and one hydrophobic that are positioned such a well-ordered fashion allowing precise assembly into a predetermined organization. A “smart” architecture in nanostructures can represent a good opportunity to use RADA16 as a carrier system for hydrophobic drugs solving problems of drugs delivery. In this work, we have investigated the diffusion properties of Pindolol, Quinine and Timolol Maleate from RADA16 in PBS and in BSS-PLUS at 37 °C. A sustained, controlled, reproducible and efficient drug release has been detected for all the systems, which has allow to understand the dependence of release kinetics on the physicochemical characteristics of RADA16 structural and chemical properties of the selected drugs and the nature of solvents used. For the analysis various physicochemical characterization techniques were used in order to investigate the state of the peptide before and after the drugs were added. Not only does RADA16 optimise drug performance, but it can also provide a solution for drug delivery issues associated with lipophilic drugs.

KW - controlled release

KW - amphiphilic hydrogels

KW - spectroscopy

KW - AFM

KW - lipophilic drugs

UR - http://www.sciencedirect.com/science/article/pii/S0378517314005912

U2 - 10.1016/j.ijpharm.2014.08.025

DO - 10.1016/j.ijpharm.2014.08.025

M3 - Article

VL - 474

SP - 103

EP - 111

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -