TY - JOUR
T1 - Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel
AU - Briuglia, Maria Lucia
AU - Urquhart, Andrew
AU - Lamprou, Dimitrios
N1 - .
“NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, [VOL 474, ISSUE 1-2, (20/08/2014)] DOI:10.1016/j.ijpharm.2014.08.025
PY - 2014/10/20
Y1 - 2014/10/20
N2 - Materials which undergo self-assembly to form supermolecular structures can provide alternative strategies to drug loading problems in controlled release application. RADA 16 is a simple and versatile self-assembling peptide with a designed structure formed of two distinct surfaces, one hydrophilic and one hydrophobic that are positioned such a well-ordered fashion allowing precise assembly into a predetermined organization. A “smart” architecture in nanostructures can represent a good opportunity to use RADA16 as a carrier system for hydrophobic drugs solving problems of drugs delivery. In this work, we have investigated the diffusion properties of Pindolol, Quinine and Timolol Maleate from RADA16 in PBS and in BSS-PLUS at 37 °C. A sustained, controlled, reproducible and efficient drug release has been detected for all the systems, which has allow to understand the dependence of release kinetics on the physicochemical characteristics of RADA16 structural and chemical properties of the selected drugs and the nature of solvents used. For the analysis various physicochemical characterization techniques were used in order to investigate the state of the peptide before and after the drugs were added. Not only does RADA16 optimise drug performance, but it can also provide a solution for drug delivery issues associated with lipophilic drugs.
AB - Materials which undergo self-assembly to form supermolecular structures can provide alternative strategies to drug loading problems in controlled release application. RADA 16 is a simple and versatile self-assembling peptide with a designed structure formed of two distinct surfaces, one hydrophilic and one hydrophobic that are positioned such a well-ordered fashion allowing precise assembly into a predetermined organization. A “smart” architecture in nanostructures can represent a good opportunity to use RADA16 as a carrier system for hydrophobic drugs solving problems of drugs delivery. In this work, we have investigated the diffusion properties of Pindolol, Quinine and Timolol Maleate from RADA16 in PBS and in BSS-PLUS at 37 °C. A sustained, controlled, reproducible and efficient drug release has been detected for all the systems, which has allow to understand the dependence of release kinetics on the physicochemical characteristics of RADA16 structural and chemical properties of the selected drugs and the nature of solvents used. For the analysis various physicochemical characterization techniques were used in order to investigate the state of the peptide before and after the drugs were added. Not only does RADA16 optimise drug performance, but it can also provide a solution for drug delivery issues associated with lipophilic drugs.
KW - controlled release
KW - amphiphilic hydrogels
KW - spectroscopy
KW - AFM
KW - lipophilic drugs
UR - http://www.sciencedirect.com/science/article/pii/S0378517314005912
U2 - 10.1016/j.ijpharm.2014.08.025
DO - 10.1016/j.ijpharm.2014.08.025
M3 - Article
SN - 0378-5173
VL - 474
SP - 103
EP - 111
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -