Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

Xiaobin Zhao; James M. Courtney

doi:10.1002/jbm.a.30925

Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

Xiaobin Zhao, James M. Courtney

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.

Original language	English
Pages (from-to)	539-553
Number of pages	14
Journal	Journal of Biomedical Materials Research Part A
Volume	80A
Issue number	3
DOIs	https://doi.org/10.1002/jbm.a.30925
Publication status	Published - 2006

Keywords

plasticized poly(vinyl chloride)
cyclodextrins
blood compatibility
protein adsorption
surface modification
polymer blending
bioengineering

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10.1002/jbm.a.30925

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title = "Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement",

abstract = "A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.",

keywords = "plasticized poly(vinyl chloride), cyclodextrins, blood compatibility, protein adsorption, surface modification, polymer blending, bioengineering",

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language = "English",

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T1 - Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

AU - Zhao, Xiaobin

AU - Courtney, James M.

PY - 2006

Y1 - 2006

N2 - A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.

AB - A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.

KW - plasticized poly(vinyl chloride)

KW - cyclodextrins

KW - blood compatibility

KW - protein adsorption

KW - surface modification

KW - polymer blending

KW - bioengineering

UR - http://dx.doi.org/10.1002/jbm.a.30925

U2 - 10.1002/jbm.a.30925

DO - 10.1002/jbm.a.30925

M3 - Article

SN - 1549-3296

VL - 80A

SP - 539

EP - 553

JO - Journal of Biomedical Materials Research Part A

JF - Journal of Biomedical Materials Research Part A

IS - 3

ER -

Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

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