Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

Xiaobin Zhao, James M. Courtney

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.
    Original languageEnglish
    Pages (from-to)539-553
    Number of pages14
    JournalJournal of Biomedical Materials Research Part A
    Volume80A
    Issue number3
    DOIs
    Publication statusPublished - 2006

    Keywords

    • plasticized poly(vinyl chloride)
    • cyclodextrins
    • blood compatibility
    • protein adsorption
    • surface modification
    • polymer blending
    • bioengineering

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