Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

Xiaobin Zhao, James M. Courtney

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.
    Original languageEnglish
    Pages (from-to)539-553
    Number of pages14
    JournalJournal of Biomedical Materials Research Part A
    Volume80A
    Issue number3
    DOIs
    Publication statusPublished - 2006

    Fingerprint

    Cyclodextrins
    Biocompatible Materials
    Biomaterials
    Surface treatment
    Polyethylene oxides
    Blood
    Polyvinyl Chloride
    Polyvinyl chlorides
    Polymers
    Vinyl Chloride
    Polypropylene oxides
    Poloxamer
    Ethylene Oxide
    Surface Properties
    Polyethylene
    Fibrinogen
    Adsorption
    Surface properties
    Polyethylenes
    Albumins

    Keywords

    • plasticized poly(vinyl chloride)
    • cyclodextrins
    • blood compatibility
    • protein adsorption
    • surface modification
    • polymer blending
    • bioengineering

    Cite this

    @article{40e65b096416483f98cfb5615a201d57,
    title = "Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement",
    abstract = "A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.",
    keywords = "plasticized poly(vinyl chloride), cyclodextrins, blood compatibility, protein adsorption, surface modification, polymer blending, bioengineering",
    author = "Xiaobin Zhao and Courtney, {James M.}",
    year = "2006",
    doi = "10.1002/jbm.a.30925",
    language = "English",
    volume = "80A",
    pages = "539--553",
    journal = "Journal of Biomedical Materials Research Part A",
    issn = "1549-3296",
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    }

    TY - JOUR

    T1 - Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement

    AU - Zhao, Xiaobin

    AU - Courtney, James M.

    PY - 2006

    Y1 - 2006

    N2 - A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.

    AB - A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.

    KW - plasticized poly(vinyl chloride)

    KW - cyclodextrins

    KW - blood compatibility

    KW - protein adsorption

    KW - surface modification

    KW - polymer blending

    KW - bioengineering

    UR - http://dx.doi.org/10.1002/jbm.a.30925

    U2 - 10.1002/jbm.a.30925

    DO - 10.1002/jbm.a.30925

    M3 - Article

    VL - 80A

    SP - 539

    EP - 553

    JO - Journal of Biomedical Materials Research Part A

    JF - Journal of Biomedical Materials Research Part A

    SN - 1549-3296

    IS - 3

    ER -