Surface modification of acetaminophen particles by atomic layer deposition

Tommi O. Kääriäinen, Marianna Kemell, Marko Vehkamäki, Marja-Leena Kääriäinen, Alexandra Correia, Hélder A. Santos, Luis M. Bimbo, Jouni Hirvonen, Pekka Hoppu, Steven M. George, David C. Cameron, Mikko Ritala, Markku Leskelä

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many APIs require processing to improve pharmaceutical formulation and manufacturing in the preparation for various drug dosage forms. Improved powder flow and protection of the APIs are often anticipated characteristics in pharmaceutical manufacturing. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD, utilizing common chemistries for Al2O3, TiO2 and ZnO, is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating process and maintains its stable polymorphic structure. Acetaminophen with nanometer scale ALD coatings shows slowed drug release. ALD TiO2 coated acetaminophen particles show cytocompatibility whereas those coated with thicker ZnO coatings exhibit the most cytotoxicity among the ALD materials under study when assessed in vitro by their effect on intestinal Caco-2 cells.
LanguageEnglish
Pages160-174
Number of pages15
JournalInternational Journal of Pharmaceutics
Volume525
Issue number1
Early online date18 Apr 2017
DOIs
Publication statusPublished - 15 Jun 2017

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Acetaminophen
Powders
Drug Compounding
Pharmaceutical Preparations
Caco-2 Cells
Dosage Forms

Keywords

  • atomic layer deposition
  • acetaminophen
  • drug release
  • cytocombatibility
  • drug delivery system
  • active pharmaceutical ingredients
  • conformal nanometer scale coatings
  • coating processes

Cite this

Kääriäinen, T. O., Kemell, M., Vehkamäki, M., Kääriäinen, M-L., Correia, A., Santos, H. A., ... Leskelä, M. (2017). Surface modification of acetaminophen particles by atomic layer deposition. International Journal of Pharmaceutics, 525(1), 160-174. https://doi.org/10.1016/j.ijpharm.2017.04.031
Kääriäinen, Tommi O. ; Kemell, Marianna ; Vehkamäki, Marko ; Kääriäinen, Marja-Leena ; Correia, Alexandra ; Santos, Hélder A. ; Bimbo, Luis M. ; Hirvonen, Jouni ; Hoppu, Pekka ; M. George, Steven ; C. Cameron, David ; Ritala, Mikko ; Leskelä, Markku . / Surface modification of acetaminophen particles by atomic layer deposition. In: International Journal of Pharmaceutics. 2017 ; Vol. 525, No. 1. pp. 160-174.
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Kääriäinen, TO, Kemell, M, Vehkamäki, M, Kääriäinen, M-L, Correia, A, Santos, HA, Bimbo, LM, Hirvonen, J, Hoppu, P, M. George, S, C. Cameron, D, Ritala, M & Leskelä, M 2017, 'Surface modification of acetaminophen particles by atomic layer deposition' International Journal of Pharmaceutics, vol. 525, no. 1, pp. 160-174. https://doi.org/10.1016/j.ijpharm.2017.04.031

Surface modification of acetaminophen particles by atomic layer deposition. / Kääriäinen, Tommi O.; Kemell, Marianna; Vehkamäki, Marko; Kääriäinen, Marja-Leena; Correia, Alexandra; Santos, Hélder A.; Bimbo, Luis M.; Hirvonen, Jouni; Hoppu, Pekka; M. George, Steven; C. Cameron, David; Ritala, Mikko; Leskelä, Markku .

In: International Journal of Pharmaceutics, Vol. 525, No. 1, 15.06.2017, p. 160-174.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Surface modification of acetaminophen particles by atomic layer deposition

AU - Kääriäinen, Tommi O.

AU - Kemell, Marianna

AU - Vehkamäki, Marko

AU - Kääriäinen, Marja-Leena

AU - Correia, Alexandra

AU - Santos, Hélder A.

AU - Bimbo, Luis M.

AU - Hirvonen, Jouni

AU - Hoppu, Pekka

AU - M. George, Steven

AU - C. Cameron, David

AU - Ritala, Mikko

AU - Leskelä, Markku

PY - 2017/6/15

Y1 - 2017/6/15

N2 - Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many APIs require processing to improve pharmaceutical formulation and manufacturing in the preparation for various drug dosage forms. Improved powder flow and protection of the APIs are often anticipated characteristics in pharmaceutical manufacturing. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD, utilizing common chemistries for Al2O3, TiO2 and ZnO, is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating process and maintains its stable polymorphic structure. Acetaminophen with nanometer scale ALD coatings shows slowed drug release. ALD TiO2 coated acetaminophen particles show cytocompatibility whereas those coated with thicker ZnO coatings exhibit the most cytotoxicity among the ALD materials under study when assessed in vitro by their effect on intestinal Caco-2 cells.

AB - Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many APIs require processing to improve pharmaceutical formulation and manufacturing in the preparation for various drug dosage forms. Improved powder flow and protection of the APIs are often anticipated characteristics in pharmaceutical manufacturing. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD, utilizing common chemistries for Al2O3, TiO2 and ZnO, is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating process and maintains its stable polymorphic structure. Acetaminophen with nanometer scale ALD coatings shows slowed drug release. ALD TiO2 coated acetaminophen particles show cytocompatibility whereas those coated with thicker ZnO coatings exhibit the most cytotoxicity among the ALD materials under study when assessed in vitro by their effect on intestinal Caco-2 cells.

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KW - drug delivery system

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KW - conformal nanometer scale coatings

KW - coating processes

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M3 - Article

VL - 525

SP - 160

EP - 174

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

Kääriäinen TO, Kemell M, Vehkamäki M, Kääriäinen M-L, Correia A, Santos HA et al. Surface modification of acetaminophen particles by atomic layer deposition. International Journal of Pharmaceutics. 2017 Jun 15;525(1):160-174. https://doi.org/10.1016/j.ijpharm.2017.04.031