Surface enhanced optical spectroscopies for bioanalysis

Iain A. Larmour, Duncan Graham

Research output: Contribution to journalLiterature review

87 Citations (Scopus)

Abstract

Surface enhancement can provide improved detection sensitivity in a range of optical spectroscopies. When applied to bioanalysis these enhanced techniques allow for the detection of disease biomarkers at lower levels, which has a clear patient benefit. However, to achieve widespread clinical use of surface enhanced techniques there remain several "grand challenges". In this review we consider the substrates employed to achieve enhancement before reviewing each enhanced optical technique in detail; surface plasmon resonance, localised surface plasmon resonance, surface enhanced fluorescence, surface enhanced infrared absorption spectroscopy and surface enhanced (resonance) Raman spectroscopy. Finally we set out the "grand challenges" currently facing the field.

LanguageEnglish
Pages3831-3853
Number of pages23
JournalAnalyst
Volume136
Issue number19
DOIs
Publication statusPublished - 2011

Fingerprint

Surface Plasmon Resonance
Spectrum Analysis
spectroscopy
Raman Spectrum Analysis
Surface plasmon resonance
Biomarkers
Fluorescence
Infrared absorption
Absorption spectroscopy
Raman spectroscopy
Infrared spectroscopy
atomic absorption spectroscopy
Optical spectroscopy
infrared spectroscopy
biomarker
fluorescence
Substrates
substrate

Keywords

  • optical spectroscopies
  • bioanalysis
  • surface plasmon resonance
  • TIC - Bionanotechnology

Cite this

Larmour, Iain A. ; Graham, Duncan. / Surface enhanced optical spectroscopies for bioanalysis. In: Analyst. 2011 ; Vol. 136, No. 19. pp. 3831-3853.
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Surface enhanced optical spectroscopies for bioanalysis. / Larmour, Iain A.; Graham, Duncan.

In: Analyst, Vol. 136, No. 19, 2011, p. 3831-3853.

Research output: Contribution to journalLiterature review

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