Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

A. de Korompay, J.C. Hill, J.F. Carter, N. NicDaeid, R. Sleeman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both δ13C and δ15N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.
LanguageEnglish
Pages1-8
Number of pages7
JournalJournal of Chromatography A
Volume1178
Issue number1-2
DOIs
Publication statusPublished - 12 Jan 2008

Fingerprint

Liquid-Liquid Extraction
Tablets
Liquids
Diatomaceous Earth
Fractionation
Isotopes

Keywords

  • 3
  • 4-methylenedioxymethylamphetamine (MDMA)
  • ecstasy tablets
  • supported liquid - liquid extraction (SLE)
  • isotopic analysis
  • isotope ratio mass spectrometry (IRMS)

Cite this

de Korompay, A. ; Hill, J.C. ; Carter, J.F. ; NicDaeid, N. ; Sleeman, R. / Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. In: Journal of Chromatography A . 2008 ; Vol. 1178, No. 1-2. pp. 1-8.
@article{249a584f45084c83835f1f31760c1476,
title = "Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis",
abstract = "A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both δ13C and δ15N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.",
keywords = "3, 4-methylenedioxymethylamphetamine (MDMA), ecstasy tablets, supported liquid - liquid extraction (SLE), isotopic analysis, isotope ratio mass spectrometry (IRMS)",
author = "{de Korompay}, A. and J.C. Hill and J.F. Carter and N. NicDaeid and R. Sleeman",
year = "2008",
month = "1",
day = "12",
doi = "10.1016/j.chroma.2007.11.054",
language = "English",
volume = "1178",
pages = "1--8",
journal = "Journal of Chromatography A",
issn = "0021-9673",
number = "1-2",

}

Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis. / de Korompay, A.; Hill, J.C.; Carter, J.F.; NicDaeid, N.; Sleeman, R.

In: Journal of Chromatography A , Vol. 1178, No. 1-2, 12.01.2008, p. 1-8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Supported liquid-liquid extraction of the active ingredient (3,4-methylenedioxymethylamphetamine) from ecstasy tablets for isotopic analysis

AU - de Korompay, A.

AU - Hill, J.C.

AU - Carter, J.F.

AU - NicDaeid, N.

AU - Sleeman, R.

PY - 2008/1/12

Y1 - 2008/1/12

N2 - A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both δ13C and δ15N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

AB - A method was developed for the isolation of 3,4-methylenedioxymethylamphetamine (MDMA) and other active ingredients from illicit ecstasy tablets. The method employed supported liquid extraction (SLE) with cartridges containing a modified form of diatomaceous earth. The method developed was simple and robust and the extract could be analysed directly, by GC-MS, to identify ingredients and reduced in volume for isotope ratio MS analysis of both δ13C and δ15N. The technique was shown to be highly reproducible, independent of the tablet matrix and considerably faster than existing liquid-liquid extraction methods. Crucially, no significant isotopic fractionation was observed as a result of the extraction process.

KW - 3

KW - 4-methylenedioxymethylamphetamine (MDMA)

KW - ecstasy tablets

KW - supported liquid - liquid extraction (SLE)

KW - isotopic analysis

KW - isotope ratio mass spectrometry (IRMS)

UR - http://dx.doi.org/10.1016/j.chroma.2007.11.054

U2 - 10.1016/j.chroma.2007.11.054

DO - 10.1016/j.chroma.2007.11.054

M3 - Article

VL - 1178

SP - 1

EP - 8

JO - Journal of Chromatography A

T2 - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 1-2

ER -