Superficial soft tissue sarcomas: 10-year survival outcomes

Maria Tolia*, Areti Gkantaifi, Larry Hayward, Girish Gupta, Anastasios Kyriazoglou, Davide Mauri, Ioanna Nixon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
27 Downloads (Pure)

Abstract

Cutaneous sarcomas comprise a broad group of rare, heterogeneous mesenchymal tumours. The present report describes a single centre experience regarding the management and the outcomes of patients with superficial soft tissue sarcomas (SSTS). Key prognostic factors in predicting overall survival (OS) and local relapse-free survival were determined. Data from 66 patients with SSTS treated surgically within Edinburgh and Lothian were collected in the context of a service evaluation. Patient demographics, tumour specifics and treatment, as well as 5-year OS and local recurrence, were analysed. Kaplan-Meier analysis was applied for survival curves, and mortality rate estimation and Cox regression were used to establish independent predictors. The mean estimated OS time was 57.2 months, with a 95% CI between 55.0 and 59.5 months. The median OS time could not be estimated because there is no time point during which the survival function has a value <50%. The death risk for a person with SSTS was increased by 7.3% (odds ratio, 1.073; 95% CI, 1.012-1.138) for every additional year of life. The estimated mean local relapse time was 58.5 months, with a 95% CI between 56 and 61 months. The median local relapse time could not be estimated since there is no time point during which the local recurrence function has a value <50%. In conclusion, out of all independent variables considered, none could statistically significantly explicate local relapse recurrence time. It is important that these rare tumours are treated in the context of a multidisciplinary team with consensus guidelines to assist decision-making.

Original languageEnglish
Article number96
Number of pages8
JournalOncology Letters
Volume25
Issue number3
Early online date27 Jan 2023
DOIs
Publication statusPublished - 31 Mar 2023

Keywords

  • outcomes
  • sarcomas
  • soft tissue
  • superficial
  • survival

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