[1H, 15N] NMR studies of the platination of phosphorothioate nucleotides − monofunctional sulfur adducts versus macrochelation

Nicole A. Kratochwil, John A. Parkinson, Cheryl Sacht, Piedad del Socorro Murdoch, Tom Brown, Peter J. Sadler

Research output: Contribution to journalArticlepeer-review

Abstract

cis-[PtI2(15NH3)2] reacts rapidly with guanosine-5′-O-(2-thiodiphosphate) (GDP-β-S) to form a macrochelate in which Pt bridges the phosphorothioate S and guanine N7 atoms. Phosphorothioate(α-S)-containing self-complementary decamer oligonucleotides give rise to relatively long lived S-bound monofunctional adducts, the fate of which is sequence dependent.
Original languageEnglish
Pages (from-to)2743-2746
Number of pages4
JournalEuropean Journal of Inorganic Chemistry
Volume2001
Issue number11
DOIs
Publication statusPublished - 20 Sept 2001

Keywords

  • platinum
  • phosphorothioate
  • macrochelation

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