Study of reproducibility of human arterial plaque reconstruction and its effects on stress analysis based on multispectral in vivo magnetic resonance imaging

Hao Gao, Quan Long, SPS Howarth, Ty Tang, Zy Li, Martin Graves, Jonathan Gillard

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Study aims to quantify the uncertainties of carotid plaque
morphology reconstruction based on patient-specific multispectral
in vivo magnetic resonance imaging (MRI) and
their impacts on the plaque stress analysis. In this study, three independent
investigators were invited to reconstruct the carotid bifurcation
with plaque based on MR images from two subjects
to study the geometry reconstruction reproducibility. Finite
element stress analyses were performed on the carotid bifurcations,
as well as the models with artificially modified
plaque geometries to mimic the image segmentation uncertainties,
to study the impacts of the uncertainties to the
stress prediction. Plaque reconstruction reproducibility was generally
high in the study. The uncertainties among interobservers
are around one or the subpixel level. It also shows
that the predicted stress is relatively less sensitive to the
arterial wall segmentation uncertainties, and more affected
by the accuracy of lipid region definition. For a model with
lipid core region artificially increased by adding one pixel on
the lipid region boundary, it will significantly increase the
maximum Von Mises Stress in fibrous cap (100%) compared
with the baseline model for all subjects.
The current in vivo MRI in the carotid plaque
could provide useful and reliable information for plaque
morphology. The accuracy of stress analysis based on plaque
geometry is subject to MRI quality. The improved resolution/
quality in plaque imaging with newly developed MRI protocols
would generate more realistic stress predictions.tudy aims t
Original languageEnglish
Pages (from-to)95-93
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number1
DOIs
Publication statusPublished - 2009

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Magnetic resonance
Stress analysis
Uncertainty
Magnetic Resonance Imaging
Imaging techniques
Lipids
Geometry
Image segmentation
Pixels

Keywords

  • carotid plaque
  • resonance images

Cite this

Gao, Hao ; Long, Quan ; Howarth, SPS ; Tang, Ty ; Li, Zy ; Graves, Martin ; Gillard, Jonathan. / Study of reproducibility of human arterial plaque reconstruction and its effects on stress analysis based on multispectral in vivo magnetic resonance imaging. In: Journal of Magnetic Resonance Imaging. 2009 ; Vol. 30, No. 1. pp. 95-93.
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abstract = "Study aims to quantify the uncertainties of carotid plaquemorphology reconstruction based on patient-specific multispectralin vivo magnetic resonance imaging (MRI) andtheir impacts on the plaque stress analysis. In this study, three independentinvestigators were invited to reconstruct the carotid bifurcationwith plaque based on MR images from two subjectsto study the geometry reconstruction reproducibility. Finiteelement stress analyses were performed on the carotid bifurcations,as well as the models with artificially modifiedplaque geometries to mimic the image segmentation uncertainties,to study the impacts of the uncertainties to thestress prediction. Plaque reconstruction reproducibility was generallyhigh in the study. The uncertainties among interobserversare around one or the subpixel level. It also showsthat the predicted stress is relatively less sensitive to thearterial wall segmentation uncertainties, and more affectedby the accuracy of lipid region definition. For a model withlipid core region artificially increased by adding one pixel onthe lipid region boundary, it will significantly increase themaximum Von Mises Stress in fibrous cap (100{\%}) comparedwith the baseline model for all subjects.The current in vivo MRI in the carotid plaquecould provide useful and reliable information for plaquemorphology. The accuracy of stress analysis based on plaquegeometry is subject to MRI quality. The improved resolution/quality in plaque imaging with newly developed MRI protocolswould generate more realistic stress predictions.tudy aims t",
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Study of reproducibility of human arterial plaque reconstruction and its effects on stress analysis based on multispectral in vivo magnetic resonance imaging. / Gao, Hao; Long, Quan; Howarth, SPS; Tang, Ty; Li, Zy; Graves, Martin; Gillard, Jonathan.

In: Journal of Magnetic Resonance Imaging, Vol. 30, No. 1, 2009, p. 95-93.

Research output: Contribution to journalArticle

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AU - Gao, Hao

AU - Long, Quan

AU - Howarth, SPS

AU - Tang, Ty

AU - Li, Zy

AU - Graves, Martin

AU - Gillard, Jonathan

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AB - Study aims to quantify the uncertainties of carotid plaquemorphology reconstruction based on patient-specific multispectralin vivo magnetic resonance imaging (MRI) andtheir impacts on the plaque stress analysis. In this study, three independentinvestigators were invited to reconstruct the carotid bifurcationwith plaque based on MR images from two subjectsto study the geometry reconstruction reproducibility. Finiteelement stress analyses were performed on the carotid bifurcations,as well as the models with artificially modifiedplaque geometries to mimic the image segmentation uncertainties,to study the impacts of the uncertainties to thestress prediction. Plaque reconstruction reproducibility was generallyhigh in the study. The uncertainties among interobserversare around one or the subpixel level. It also showsthat the predicted stress is relatively less sensitive to thearterial wall segmentation uncertainties, and more affectedby the accuracy of lipid region definition. For a model withlipid core region artificially increased by adding one pixel onthe lipid region boundary, it will significantly increase themaximum Von Mises Stress in fibrous cap (100%) comparedwith the baseline model for all subjects.The current in vivo MRI in the carotid plaquecould provide useful and reliable information for plaquemorphology. The accuracy of stress analysis based on plaquegeometry is subject to MRI quality. The improved resolution/quality in plaque imaging with newly developed MRI protocolswould generate more realistic stress predictions.tudy aims t

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