Studies of the regulated assembly of SNARE complexes in adipocytes

Dimitrios Kioumourtzoglou, Jessica B.A. Sadler, Hannah L. Black, Rebecca Berends, Cassie Wellburn, Nia J. Bryant, Gwyn W. Gould

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Insulin plays a fundamental role inwhole-body glucose homeostasis. Central to this is the hormone's ability to rapidly stimulate the rate of glucose transport into adipocytes andmuscle cells [1]. Upon binding its receptor, insulin stimulates an intracellular signalling cascade that culminates in redistribution of glucose transporter proteins, specifically the GLUT4 isoform, from intracellular stores to the plasma membrane, a process termed 'translocation' [1,2]. This is an example of regulated membrane trafficking [3], a process that also underpins other aspects of physiology in a number of specialized cell types, for example neurotransmission in brain/neurons and release of hormone-containing vesicles from specialized secretory cells such as those found in pancreatic islets. These processes invoke a number of intriguing biological questions as follows. How is the machinery involved in these membrane trafficking events mobilized in response to a stimulus? How do the signalling pathways that detect the external stimulus interface with the trafficking machinery? Recent studies of insulin-stimulated GLUT4 translocation offer insight into such questions. In the present paper, we have reviewed these studies and draw parallels with other regulated trafficking systems.

LanguageEnglish
Pages1396-1400
Number of pages5
JournalBiochemical Society Transactions
Volume42
Issue number5
DOIs
Publication statusPublished - 31 Oct 2014

Fingerprint

SNARE Proteins
Adipocytes
Machinery
Glucose Transporter Type 4
Hormones
Insulin
Membranes
Glucose
Facilitative Glucose Transport Proteins
Insulin Receptor
Physiology
Secretory Vesicles
Cell membranes
Islets of Langerhans
Synaptic Transmission
Neurons
Brain
Protein Isoforms
Homeostasis
Cell Count

Keywords

  • insulin
  • membrane fusion
  • phosphorylation
  • Sec1/Munc18 protein
  • soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE)

Cite this

Kioumourtzoglou, D., Sadler, J. B. A., Black, H. L., Berends, R., Wellburn, C., Bryant, N. J., & Gould, G. W. (2014). Studies of the regulated assembly of SNARE complexes in adipocytes. Biochemical Society Transactions, 42(5), 1396-1400. https://doi.org/10.1042/BST20140114
Kioumourtzoglou, Dimitrios ; Sadler, Jessica B.A. ; Black, Hannah L. ; Berends, Rebecca ; Wellburn, Cassie ; Bryant, Nia J. ; Gould, Gwyn W. / Studies of the regulated assembly of SNARE complexes in adipocytes. In: Biochemical Society Transactions. 2014 ; Vol. 42, No. 5. pp. 1396-1400.
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Kioumourtzoglou, D, Sadler, JBA, Black, HL, Berends, R, Wellburn, C, Bryant, NJ & Gould, GW 2014, 'Studies of the regulated assembly of SNARE complexes in adipocytes' Biochemical Society Transactions, vol. 42, no. 5, pp. 1396-1400. https://doi.org/10.1042/BST20140114

Studies of the regulated assembly of SNARE complexes in adipocytes. / Kioumourtzoglou, Dimitrios; Sadler, Jessica B.A.; Black, Hannah L.; Berends, Rebecca; Wellburn, Cassie; Bryant, Nia J.; Gould, Gwyn W.

In: Biochemical Society Transactions, Vol. 42, No. 5, 31.10.2014, p. 1396-1400.

Research output: Contribution to journalReview article

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Kioumourtzoglou D, Sadler JBA, Black HL, Berends R, Wellburn C, Bryant NJ et al. Studies of the regulated assembly of SNARE complexes in adipocytes. Biochemical Society Transactions. 2014 Oct 31;42(5):1396-1400. https://doi.org/10.1042/BST20140114