STS blood conservation guidelines: the role of leukocyte filtration

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The inference that neutrophils trapped by leukocyte filters may exacerbate inflammatory mechanisms is not new, and this has been widely discussed in the clinical world. This suggestion stems from the work of Scholz and colleagues [3] who observed that leukocyte filtration failed to limit neutrophil stimulation and augmented polymorphonuclear leukocyte elastase levels. Although some have tried to argue that increasing the circulating elastase may break down the structural protein elastin that holds endothelial cells together, and in this way may worsen clinical outcome, critically, the authors in this particular study noted that "we did not find clinical disadvantages related to any filtration strategy tested." This conclusion supports our belief that the assay used to measure elastase can not distinguish between active and inactive elastase. Therefore, the functional significance of having elevated elastase levels, as measured by the available technology, is not really known.
    LanguageEnglish
    Pages1138-1139
    Number of pages1
    JournalAnnals of Thoracic Surgery
    Volume85
    Issue number3
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Pancreatic Elastase
    Leukocytes
    Guidelines
    Neutrophils
    Leukocyte Elastase
    Elastin
    Endothelial Cells
    Technology
    Proteins

    Keywords

    • STS blood conservation
    • leukocyte filtration
    • bioengineering

    Cite this

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    title = "STS blood conservation guidelines: the role of leukocyte filtration",
    abstract = "The inference that neutrophils trapped by leukocyte filters may exacerbate inflammatory mechanisms is not new, and this has been widely discussed in the clinical world. This suggestion stems from the work of Scholz and colleagues [3] who observed that leukocyte filtration failed to limit neutrophil stimulation and augmented polymorphonuclear leukocyte elastase levels. Although some have tried to argue that increasing the circulating elastase may break down the structural protein elastin that holds endothelial cells together, and in this way may worsen clinical outcome, critically, the authors in this particular study noted that {"}we did not find clinical disadvantages related to any filtration strategy tested.{"} This conclusion supports our belief that the assay used to measure elastase can not distinguish between active and inactive elastase. Therefore, the functional significance of having elevated elastase levels, as measured by the available technology, is not really known.",
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    author = "T. Gourlay and A.H. Olivencia-Yurvati and S. Gunaydin",
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    STS blood conservation guidelines: the role of leukocyte filtration. / Gourlay, T.; Olivencia-Yurvati, A.H.; Gunaydin, S.

    In: Annals of Thoracic Surgery, Vol. 85, No. 3, 2008, p. 1138-1139.

    Research output: Contribution to journalArticle

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    AU - Olivencia-Yurvati, A.H.

    AU - Gunaydin, S.

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    AB - The inference that neutrophils trapped by leukocyte filters may exacerbate inflammatory mechanisms is not new, and this has been widely discussed in the clinical world. This suggestion stems from the work of Scholz and colleagues [3] who observed that leukocyte filtration failed to limit neutrophil stimulation and augmented polymorphonuclear leukocyte elastase levels. Although some have tried to argue that increasing the circulating elastase may break down the structural protein elastin that holds endothelial cells together, and in this way may worsen clinical outcome, critically, the authors in this particular study noted that "we did not find clinical disadvantages related to any filtration strategy tested." This conclusion supports our belief that the assay used to measure elastase can not distinguish between active and inactive elastase. Therefore, the functional significance of having elevated elastase levels, as measured by the available technology, is not really known.

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