Structure based evolution of a novel series of positive modulators of the AMPA receptor

Craig Jamieson, John K.F. Maclean, Christopher I Brown, Robert A Campbell, Kevin J. Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, YVONNE LAMONT, Amanda J. Lyons, Elizabeth M. Moir, John A. Morrow, John Pantling, Zoran Rankovic, Lynn Smith

Research output: Contribution to journalArticle

26 Citations (Scopus)
100 Downloads (Pure)

Abstract

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X
Original languageEnglish
Pages (from-to)805-811
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume 21
Issue number2
DOIs
Publication statusPublished - 15 Jan 2011

Keywords

  • AMPA receptor
  • allosteric modulator
  • SBDD
  • indane
  • scaffold hopping

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  • Projects

    JARL Start Up Funding

    Jamieson, C.

    1/04/11 → …

    Project: Internally funded project

    Research Output

    • 26 Citations
    • 1 Chapter

    AMPA receptor positive modulators

    Jamieson, C., Morrow, J. & Maclean, J., Jul 2012, Targets and Emerging Therapies for Schizophrenia. Albert, J. & Wood, M. (eds.). 1 ed. Hoboken, NJ, p. 187-231 44 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cite this

    Jamieson, C., Maclean, J. K. F., Brown, C. I., Campbell, R. A., Gillen, K. J., Gillespie, J., ... Smith, L. (2011). Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorganic and Medicinal Chemistry Letters, 21(2), 805-811. https://doi.org/10.1016/j.bmcl.2010.11.098