Structure based evolution of a novel series of positive modulators of the AMPA receptor

Craig Jamieson; John K.F. Maclean; Christopher I Brown; Robert A Campbell; Kevin J. Gillen; Jonathan Gillespie; Bert Kazemier; Michael Kiczun; YVONNE LAMONT; Amanda J. Lyons; Elizabeth M. Moir; John A. Morrow; John Pantling; Zoran Rankovic; Lynn Smith

doi:10.1016/j.bmcl.2010.11.098

Structure based evolution of a novel series of positive modulators of the AMPA receptor

Craig Jamieson, John K.F. Maclean, Christopher I Brown, Robert A Campbell, Kevin J. Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, YVONNE LAMONT, Amanda J. Lyons, Elizabeth M. Moir, John A. Morrow, John Pantling, Zoran Rankovic, Lynn Smith

Pure And Applied Chemistry

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Abstract

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X

Original language	English
Pages (from-to)	805-811
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2010.11.098
Publication status	Published - 15 Jan 2011

Keywords

AMPA receptor
allosteric modulator
SBDD
indane
scaffold hopping

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10.1016/j.bmcl.2010.11.098

Jamieson-etal-BMCL-2011-Structure-based-evolution-of-a-novel-series-of-positive-modulatorsAccepted author manuscript, 824 KBLicence: CC BY-NC-ND 4.0

Cite this

Jamieson, C., Maclean, J. K. F., Brown, C. I., Campbell, R. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., LAMONT, YVONNE., Lyons, A. J., Moir, E. M., Morrow, J. A., Pantling, J., Rankovic, Z., & Smith, L. (2011). Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorganic and Medicinal Chemistry Letters, 21(2), 805-811. https://doi.org/10.1016/j.bmcl.2010.11.098

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title = "Structure based evolution of a novel series of positive modulators of the AMPA receptor",

abstract = "Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X",

keywords = "AMPA receptor , allosteric modulator, SBDD, indane, scaffold hopping",

author = "Craig Jamieson and Maclean, {John K.F.} and Brown, {Christopher I} and Campbell, {Robert A} and Gillen, {Kevin J.} and Jonathan Gillespie and Bert Kazemier and Michael Kiczun and YVONNE LAMONT and Lyons, {Amanda J.} and Moir, {Elizabeth M.} and Morrow, {John A.} and John Pantling and Zoran Rankovic and Lynn Smith",

year = "2011",

month = jan,

day = "15",

doi = "10.1016/j.bmcl.2010.11.098",

language = "English",

volume = " 21",

pages = "805--811",

journal = "Bioorganic and Medicinal Chemistry Letters",

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Jamieson, C, Maclean, JKF, Brown, CI, Campbell, RA, Gillen, KJ, Gillespie, J, Kazemier, B, Kiczun, M, LAMONT, YVONNE, Lyons, AJ, Moir, EM, Morrow, JA, Pantling, J, Rankovic, Z & Smith, L 2011, 'Structure based evolution of a novel series of positive modulators of the AMPA receptor', Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 2, pp. 805-811. https://doi.org/10.1016/j.bmcl.2010.11.098

TY - JOUR

T1 - Structure based evolution of a novel series of positive modulators of the AMPA receptor

AU - Jamieson, Craig

AU - Maclean, John K.F.

AU - Brown, Christopher I

AU - Campbell, Robert A

AU - Gillen, Kevin J.

AU - Gillespie, Jonathan

AU - Kazemier, Bert

AU - Kiczun, Michael

AU - LAMONT, YVONNE

AU - Lyons, Amanda J.

AU - Moir, Elizabeth M.

AU - Morrow, John A.

AU - Pantling, John

AU - Rankovic, Zoran

AU - Smith, Lynn

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X

AB - Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X

KW - AMPA receptor

KW - allosteric modulator

KW - SBDD

KW - indane

KW - scaffold hopping

UR - https://www.sciencedirect.com/journal/bioorganic-and-medicinal-chemistry-letters

U2 - 10.1016/j.bmcl.2010.11.098

DO - 10.1016/j.bmcl.2010.11.098

M3 - Article

SN - 0960-894X

VL - 21

SP - 805

EP - 811

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Structure based evolution of a novel series of positive modulators of the AMPA receptor

Abstract

Keywords

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JARL Start Up Funding

AMPA receptor positive modulators

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Structure based evolution of a novel series of positive modulators of the AMPA receptor

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

JARL Start Up Funding

Research output

AMPA receptor positive modulators

Cite this