Structure based evolution of a novel series of positive modulators of the AMPA receptor

Craig Jamieson, John K.F. Maclean, Christopher I Brown, Robert A Campbell, Kevin J. Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, YVONNE LAMONT, Amanda J. Lyons, Elizabeth M. Moir, John A. Morrow, John Pantling, Zoran Rankovic, Lynn Smith

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotyope with a promising overall profile, exemplified by X
LanguageEnglish
Pages805-811
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume 21
Issue number2
DOIs
Publication statusPublished - 15 Jan 2011

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AMPA Receptors
Modulators

Keywords

  • AMPA receptor
  • allosteric modulator
  • SBDD
  • indane
  • scaffold hopping

Cite this

Jamieson, C., Maclean, J. K. F., Brown, C. I., Campbell, R. A., Gillen, K. J., Gillespie, J., ... Smith, L. (2011). Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorganic and Medicinal Chemistry Letters, 21(2), 805-811. https://doi.org/10.1016/j.bmcl.2010.11.098
Jamieson, Craig ; Maclean, John K.F. ; Brown, Christopher I ; Campbell, Robert A ; Gillen, Kevin J. ; Gillespie, Jonathan ; Kazemier, Bert ; Kiczun, Michael ; LAMONT, YVONNE ; Lyons, Amanda J. ; Moir, Elizabeth M. ; Morrow, John A. ; Pantling, John ; Rankovic, Zoran ; Smith, Lynn. / Structure based evolution of a novel series of positive modulators of the AMPA receptor. In: Bioorganic and Medicinal Chemistry Letters. 2011 ; Vol. 21, No. 2. pp. 805-811.
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author = "Craig Jamieson and Maclean, {John K.F.} and Brown, {Christopher I} and Campbell, {Robert A} and Gillen, {Kevin J.} and Jonathan Gillespie and Bert Kazemier and Michael Kiczun and YVONNE LAMONT and Lyons, {Amanda J.} and Moir, {Elizabeth M.} and Morrow, {John A.} and John Pantling and Zoran Rankovic and Lynn Smith",
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Jamieson, C, Maclean, JKF, Brown, CI, Campbell, RA, Gillen, KJ, Gillespie, J, Kazemier, B, Kiczun, M, LAMONT, YVONNE, Lyons, AJ, Moir, EM, Morrow, JA, Pantling, J, Rankovic, Z & Smith, L 2011, 'Structure based evolution of a novel series of positive modulators of the AMPA receptor' Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 2, pp. 805-811. https://doi.org/10.1016/j.bmcl.2010.11.098

Structure based evolution of a novel series of positive modulators of the AMPA receptor. / Jamieson, Craig; Maclean, John K.F.; Brown, Christopher I; Campbell, Robert A; Gillen, Kevin J.; Gillespie, Jonathan; Kazemier, Bert; Kiczun, Michael; LAMONT, YVONNE; Lyons, Amanda J.; Moir, Elizabeth M.; Morrow, John A.; Pantling, John; Rankovic, Zoran; Smith, Lynn.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 2, 15.01.2011, p. 805-811.

Research output: Contribution to journalArticle

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AU - Maclean, John K.F.

AU - Brown, Christopher I

AU - Campbell, Robert A

AU - Gillen, Kevin J.

AU - Gillespie, Jonathan

AU - Kazemier, Bert

AU - Kiczun, Michael

AU - LAMONT, YVONNE

AU - Lyons, Amanda J.

AU - Moir, Elizabeth M.

AU - Morrow, John A.

AU - Pantling, John

AU - Rankovic, Zoran

AU - Smith, Lynn

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KW - allosteric modulator

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KW - indane

KW - scaffold hopping

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JO - Bioorganic and Medicinal Chemistry Letters

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