Structure and aggregation of a helix-forming polymer

James E. Magee, Zhankai Song, Robin A. Curtis, L. Lue

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We have studied the competition between helix formation and aggregation for a simple polymer model. We present simulation results for a system of two such polymers, examining the potential of mean force, the balance between intermolecular and intramolecular interactions, and the promotion or disruption of secondary structure brought on by the proximity of the two molecules. In particular, we demonstrate that proximity between two such molecules can stabilize secondary structure. However, for this model, observed secondary structure is not stable enough to prevent collapse of the system into an unstructured globule.
Original languageEnglish
Article number144911
Number of pages9
JournalJournal of Chemical Physics
Issue number14
Publication statusPublished - 14 Apr 2007


  • polymer structure
  • molecular biophysics
  • intermolecular forces
  • aggregation


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