Structural tracking of the potassium-mediated magnesiation of anisole

W. Clegg, B. Conway, P. Garcia-Alvarez, A.R. Kennedy, R.E. Mulvey, L. Russo, J. Sassmannshausen, Tell Tuttle

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The potassium-mediated magnesiation of anisole has been monitored by a combination of X-ray crystallographic and NMR spectroscopic studies. Departing from a heteroleptic alkyl-amido base and anisole, the reaction first stops at an ortho-magnesiated anisole intermediate, but the final destination is an ortho-magnesiated anisole complex with reincorporation of the amine ligand and elimination of alkane (see picture).
LanguageEnglish
Pages10702-10706
Number of pages4
JournalChemistry - A European Journal
Volume15
Issue number41
DOIs
Publication statusPublished - 2009

Fingerprint

Potassium
Alkanes
Amines
Nuclear magnetic resonance
Ligands
X rays
anisole

Keywords

  • crystal structure
  • magnesiation
  • metalation
  • NMR spectroscopy
  • potassium

Cite this

Clegg, W. ; Conway, B. ; Garcia-Alvarez, P. ; Kennedy, A.R. ; Mulvey, R.E. ; Russo, L. ; Sassmannshausen, J. ; Tuttle, Tell. / Structural tracking of the potassium-mediated magnesiation of anisole. In: Chemistry - A European Journal. 2009 ; Vol. 15, No. 41. pp. 10702-10706.
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Structural tracking of the potassium-mediated magnesiation of anisole. / Clegg, W.; Conway, B.; Garcia-Alvarez, P.; Kennedy, A.R.; Mulvey, R.E.; Russo, L.; Sassmannshausen, J.; Tuttle, Tell.

In: Chemistry - A European Journal, Vol. 15, No. 41, 2009, p. 10702-10706.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Structural tracking of the potassium-mediated magnesiation of anisole

AU - Clegg, W.

AU - Conway, B.

AU - Garcia-Alvarez, P.

AU - Kennedy, A.R.

AU - Mulvey, R.E.

AU - Russo, L.

AU - Sassmannshausen, J.

AU - Tuttle, Tell

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KW - crystal structure

KW - magnesiation

KW - metalation

KW - NMR spectroscopy

KW - potassium

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