Structural instability in an autophosphorylating kinase switch

M. Grinfeld; S.D. Webb

doi:10.1016/j.mbs.2009.02.005

Structural instability in an autophosphorylating kinase switch

M. Grinfeld, S.D. Webb

Mathematics And Statistics

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Abstract

We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into account.

Original language	English
Pages (from-to)	92-96
Number of pages	5
Journal	Mathematical Biosciences
Volume	219
Issue number	2
DOIs	https://doi.org/10.1016/j.mbs.2009.02.005
Publication status	Published - Jun 2009

Keywords

bistability
protein turnover
structural instability
numerical mathematics
statistics

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10.1016/j.mbs.2009.02.005

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title = "Structural instability in an autophosphorylating kinase switch",

abstract = "We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into account.",

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KW - structural instability

KW - numerical mathematics

KW - statistics

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DO - 10.1016/j.mbs.2009.02.005

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JO - Mathematical Biosciences

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Structural instability in an autophosphorylating kinase switch

Abstract

Keywords

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