Structural instability in an autophosphorylating kinase switch

M. Grinfeld, S.D. Webb

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into account.
LanguageEnglish
Pages92-96
Number of pages5
JournalMathematical Biosciences
Volume219
Issue number2
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Bistability
Switch
phosphotransferases (kinases)
Degradation
Phosphotransferases
Switches
Synthesis
Proteins
Protein
protein metabolism
synthesis
degradation
Model

Keywords

  • bistability
  • protein turnover
  • structural instability
  • numerical mathematics
  • statistics

Cite this

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title = "Structural instability in an autophosphorylating kinase switch",
abstract = "We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into account.",
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Structural instability in an autophosphorylating kinase switch. / Grinfeld, M.; Webb, S.D.

In: Mathematical Biosciences, Vol. 219, No. 2, 06.2009, p. 92-96.

Research output: Contribution to journalArticle

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AU - Webb, S.D.

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KW - numerical mathematics

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