Structural hierarchy of biomimetic materials for tissue engineered vascular and orthopedic grafts

C Lekakou; D Lamprou; U Vidyarthi; E Karopoulou; P Zhdan

doi:10.1002/jbm.b.30966

Structural hierarchy of biomimetic materials for tissue engineered vascular and orthopedic grafts

C Lekakou, D Lamprou, U Vidyarthi, E Karopoulou, P Zhdan

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Gelatine gels and gelatine/elastin gels have been prepared to be used in tissue engineered vascular grafts. Optical microscopy and atomic force microscopy (AFM) revealed that the gelatine formed nanofibrils as in soft collagen tissues. The gelatine/elastin gels were nanocomposites with flat elastin nanodomains embedded in the gelatine matrix mimicking the structure of the tunica media in arteries. Gelatine/"hydroxyapatite" (HA) nanocomposites were prepared with the in situ production of "HA" in solution. AFM revealed "HA" solid nanoparticles of about 20 nm size embedded in the gelatine matrix, which formed a hierarchical structure similar to that of the collagen matrix in bone. The application of amagnetic field of 9.4 T resulted in the elongation and orientation of gelatine particles and orientation of gelatine microfibrils in a direction perpendicular to that of the magnetic field.

Original language	English
Pages (from-to)	461-468
Number of pages	8
Journal	Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume	85B
Issue number	2
DOIs	https://doi.org/10.1002/jbm.b.30966
Publication status	Published - May 2008

Keywords

biomimetic
bone graft
microstructure
vascular graft

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title = "Structural hierarchy of biomimetic materials for tissue engineered vascular and orthopedic grafts",

abstract = "Gelatine gels and gelatine/elastin gels have been prepared to be used in tissue engineered vascular grafts. Optical microscopy and atomic force microscopy (AFM) revealed that the gelatine formed nanofibrils as in soft collagen tissues. The gelatine/elastin gels were nanocomposites with flat elastin nanodomains embedded in the gelatine matrix mimicking the structure of the tunica media in arteries. Gelatine/{"}hydroxyapatite{"} (HA) nanocomposites were prepared with the in situ production of {"}HA{"} in solution. AFM revealed {"}HA{"} solid nanoparticles of about 20 nm size embedded in the gelatine matrix, which formed a hierarchical structure similar to that of the collagen matrix in bone. The application of amagnetic field of 9.4 T resulted in the elongation and orientation of gelatine particles and orientation of gelatine microfibrils in a direction perpendicular to that of the magnetic field. ",

keywords = "biomimetic, bone graft, microstructure, vascular graft",

author = "C Lekakou and D Lamprou and U Vidyarthi and E Karopoulou and P Zhdan",

year = "2008",

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doi = "10.1002/jbm.b.30966",

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T1 - Structural hierarchy of biomimetic materials for tissue engineered vascular and orthopedic grafts

AU - Lekakou, C

AU - Lamprou, D

AU - Vidyarthi, U

AU - Karopoulou, E

AU - Zhdan, P

PY - 2008/5

Y1 - 2008/5

N2 - Gelatine gels and gelatine/elastin gels have been prepared to be used in tissue engineered vascular grafts. Optical microscopy and atomic force microscopy (AFM) revealed that the gelatine formed nanofibrils as in soft collagen tissues. The gelatine/elastin gels were nanocomposites with flat elastin nanodomains embedded in the gelatine matrix mimicking the structure of the tunica media in arteries. Gelatine/"hydroxyapatite" (HA) nanocomposites were prepared with the in situ production of "HA" in solution. AFM revealed "HA" solid nanoparticles of about 20 nm size embedded in the gelatine matrix, which formed a hierarchical structure similar to that of the collagen matrix in bone. The application of amagnetic field of 9.4 T resulted in the elongation and orientation of gelatine particles and orientation of gelatine microfibrils in a direction perpendicular to that of the magnetic field.

AB - Gelatine gels and gelatine/elastin gels have been prepared to be used in tissue engineered vascular grafts. Optical microscopy and atomic force microscopy (AFM) revealed that the gelatine formed nanofibrils as in soft collagen tissues. The gelatine/elastin gels were nanocomposites with flat elastin nanodomains embedded in the gelatine matrix mimicking the structure of the tunica media in arteries. Gelatine/"hydroxyapatite" (HA) nanocomposites were prepared with the in situ production of "HA" in solution. AFM revealed "HA" solid nanoparticles of about 20 nm size embedded in the gelatine matrix, which formed a hierarchical structure similar to that of the collagen matrix in bone. The application of amagnetic field of 9.4 T resulted in the elongation and orientation of gelatine particles and orientation of gelatine microfibrils in a direction perpendicular to that of the magnetic field.

KW - biomimetic

KW - bone graft

KW - microstructure

KW - vascular graft

U2 - 10.1002/jbm.b.30966

DO - 10.1002/jbm.b.30966

M3 - Article

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JO - Journal of Biomedical Materials Research Part B: Applied Biomaterials

JF - Journal of Biomedical Materials Research Part B: Applied Biomaterials

SN - 1552-4973

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ER -